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Recognizing Severe Adverse Drug Reactions: Two Case Reports After Switching Therapies to the Same Generic Company.

Author: ArgentieriAngela, CaroleoMaria C, CioneErika, CodamoGiuseppe, De SarroGiovambattista, GallelliGiuseppe, GallelliLuca, LongoPaola, MichniewiczAndzelika, SiniscalchiAntonio, StefanelliRoberta

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This report describes the development of Adverse Drug Reactions (ADRs) in two patients after the switch from brand to generic formulations. We have tested cytochrome P450 enzymes expression as well as drug serum levels. Checking deeply into both patient's medical history, they harbored poly-sensitivity or allergy to pollen and graminacea. We strongly suggest to both pharmacists and physicians to be careful in giving the advice to change the drug, thinking to reduce health sanitary costs without considering the personal clinical history of each one.
Paper Details　
Original Abstract of the Article :
Generic formulations represent a way to reduce the costs of brand compounds when their patent is expired. While, the bio-equivalence in generic drugs is guaranteed, some excipients as well as dyes could be different and this could reduce the drug safety. Herein, we report the development of Adverse ...See full text at original site
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引用元：
https://doi.org/10.2174/1574886311207040309

データ提供：米国国立医学図書館（NLM）

Navigating the World of Generic Medications: A Cautionary Tale

The [pharmaceutical industry] is a complex and ever-evolving landscape, constantly striving to improve the accessibility and affordability of medications. The introduction of [generic formulations] has significantly reduced healthcare costs, but it's essential to consider the potential implications of switching from [branded drugs] to [generic equivalents]. This study raises concerns about the safety of [generic formulations], reporting cases of [adverse drug reactions (ADRs)] in patients who switched from [branded drugs] to [generic drugs] produced by the same company. The authors emphasize the need for caution and careful consideration of individual patient histories when making decisions about medication switches.

The Complexities of Generic Formulations: Beyond Bioequivalence

This study underscores the importance of considering factors beyond simply [bioequivalence] when evaluating the safety of [generic formulations]. The authors highlight the potential for differences in [excipients] and [dyes] between [branded] and [generic] medications, which could lead to [ADRs] in some individuals. This research calls for greater transparency and rigorous testing to ensure the safety and efficacy of all [generic formulations].

Navigating the Desert of Medication Choices: Informed Decisions

As a camel navigating the vast desert of [pharmaceutical choices], I've learned that even seemingly minor variations can make a big difference. This study reminds us to approach medication switches with caution and careful consideration of individual patient histories. It's essential to engage in open conversations with healthcare professionals about any concerns or questions regarding the potential risks and benefits of switching to [generic formulations].

Dr. Camel's Conclusion

This research serves as a cautionary tale about the potential risks associated with [generic formulations]. While [generics] can offer significant cost savings, it's crucial to prioritize patient safety and consider individual patient needs when making medication decisions. By promoting transparency and rigorous testing, we can ensure that [generic medications] provide both affordable and safe options for patients.

Date :
  1. Date Completed 2016-12-13
  2. Date Revised 2019-11-13
Further Info :

Pubmed ID

26412669

DOI: Digital Object Identifier

10.2174/1574886311207040309

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English

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