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Prothrombin Complex Concentrate Is Effective in Treating the Anticoagulant Effects of Dabigatran in a Porcine Polytrauma Model.

Author: BraunschweigTill, GrottkeOliver, HonickelMarkus, RossaintRolf, SpronkHenri M H, Ten CateHugo, van RynJoanne

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated four-factor prothrombin complex concentrate (PCC) for treating dabigatran-induced anticoagulation in a porcine polytrauma model. No specific reversal agents are routinely available for the direct oral anticoagulants such as dabigatran.
Paper Details　
Original Abstract of the Article :
In the event of trauma, emergency reversal of anticoagulation therapy may be required. However, no specific reversal agents are routinely available for the direct oral anticoagulants such as dabigatran. The authors investigated four-factor prothrombin complex concentrate (PCC) for treating dabigatra...See full text at original site
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引用元：
https://doi.org/10.1097/ALN.0000000000000863

データ提供：米国国立医学図書館（NLM）

Dabigatran Reversal: A Race Against Time in Trauma

The desert of trauma is a challenging landscape, where quick and decisive action is crucial for saving lives. This study, like a team of researchers exploring the complex world of anticoagulation reversal, investigates the effectiveness of prothrombin complex concentrate (PCC) in reversing the anticoagulant effects of dabigatran in a porcine polytrauma model. The authors, facing the urgent need for rapid reversal of anticoagulation in trauma settings, explore the potential of PCC to restore normal coagulation in the presence of dabigatran. Their findings offer valuable insights into the potential of PCC as a promising agent for managing anticoagulation reversal in traumatic situations.

A Timely Solution: PCC's Potential in Dabigatran Reversal

The study demonstrates the effectiveness of PCC in reversing the anticoagulant effects of dabigatran, offering a potential solution for the urgent need for rapid anticoagulation reversal in trauma patients. The researchers found that PCC effectively restored normal coagulation in the porcine model, highlighting its potential as a valuable tool for managing dabigatran-induced anticoagulation in emergency settings. This research, like a lifeline in the desert, provides a potential solution for a critical challenge in trauma care.

Dr. Camel's Conclusion

This study underscores the potential of PCC to effectively reverse the anticoagulant effects of dabigatran in traumatic situations, providing a crucial tool for managing anticoagulation reversal in emergency settings. This research, like a beacon of hope in the desert of trauma, offers a promising solution for a critical challenge in patient care.

Date :
  1. Date Completed 2016-04-06
  2. Date Revised 2015-12-15
Further Info :

Pubmed ID

26414500

DOI: Digital Object Identifier

10.1097/ALN.0000000000000863

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SNS
PICO Info
in preparation
Languages

English

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