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Multiplex Brain Proteomic Analysis Revealed the Molecular Therapeutic Effects of Buyang Huanwu Decoction on Cerebral Ischemic Stroke Mice.

Author: ChenHong-Jhang, ChenYet-Ran, HsiehPei-Hsuan, HsuWei-Hsiang, LeeChi-Ying, LinYun-Lian, LiouKuo-Tong, ShenYuh-Chiang, ShiaoYoung-Ji

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compared the effects of tissue plasminogen activator (TPA) and Buyang Huanwu Decoction (BHD) in a mouse model of cerebral ischemia/reperfusion injury. The results suggest that BHD may be a promising treatment option for ischemic stroke.
Paper Details　
Original Abstract of the Article :
Stroke is the second-leading cause of death worldwide, and tissue plasminogen activator (TPA) is the only drug used for a limited group of stroke patients in the acute phase. Buyang Huanwu Decoction (BHD), a traditional Chinese medicine prescription, has long been used for improving neurological fun...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619651/

データ提供：米国国立医学図書館（NLM）

Buyang Huanwu Decoction: A Traditional Remedy for Stroke

Stroke, like a sudden desert storm, can devastate the brain and leave lasting consequences. This study explores the potential therapeutic effects of Buyang Huanwu Decoction (BHD), a traditional Chinese medicine prescription, in treating cerebral ischemic stroke in mice. The authors used a mouse model of stroke to investigate the molecular mechanisms by which BHD exerts its therapeutic effects. They employed a multiplex proteomics approach to analyze changes in protein expression in the brain after stroke and after treatment with BHD or tissue plasminogen activator (TPA).

BHD: A Multifaceted Approach

The study found that BHD treatment preserved the integrity of the blood-brain barrier (BBB), suppressed excitotoxicity, and enhanced energy metabolism in the brain. These effects suggest that BHD may protect the brain from damage caused by stroke. Furthermore, the study identified an increase in neurogenesis markers and a decrease in the activity of GSK-3 and Tau, indicating that BHD may promote neuroprotection and neuronal repair.

A Traditional Remedy with Modern Promise

This study provides compelling evidence for the potential of BHD as a therapeutic agent for ischemic stroke. The authors' research highlights the multifaceted effects of BHD, suggesting that this traditional remedy may offer a promising approach for treating stroke. Their findings encourage further research into the clinical applications of BHD for stroke treatment.

Dr. Camel's Conclusion

This study is a fascinating journey through the desert of traditional medicine, revealing the potential of Buyang Huanwu Decoction (BHD) as a therapeutic agent for stroke. The authors' meticulous research, like a map guiding us through the complexities of stroke recovery, uncovers the multifaceted effects of BHD, offering hope for new treatments and strategies to combat this devastating condition.

Date :
  1. Date Completed 2016-06-20
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

26492191

DOI: Digital Object Identifier

PMC4619651

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Languages

English

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