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Effects of Vitamin K3 and K5 on Daunorubicin-resistant Human T Lymphoblastoid Leukemia Cells.

Author: HiranoToshihiko, NakaokaEri, OndaKenji, SugiyamaKentaro, TanakaSachiko

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study found that vitamins K3 and K5 inhibited the proliferation of leukemia cells and were effective against drug-resistant cells.
Paper Details　
Original Abstract of the Article :
BACKGROUND/AIM: Anticancer efficacy of vitamin K derivatives on multidrug-resistant cancer cells has been scarcely investigated. MATERIALS AND METHODS: The effects of vitamins K3 and K5 on proliferation of human leukemia MOLT-4 cells and on daunorubicin-resistant MOLT-4/DNR cells were estimated by ...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://pubmed.ncbi.nlm.nih.gov/26504027

データ提供：米国国立医学図書館（NLM）

Vitamin K Derivatives: A New Oasis in the Desert of Drug Resistance

Cancer cells can develop resistance to chemotherapy drugs, making treatment more challenging. This study investigates the potential of vitamin K derivatives, specifically vitamin K3 and K5, to overcome drug resistance in human leukemia cells. The study examined the effects of vitamin K3 and K5 on the proliferation of human leukemia MOLT-4 cells, both in their standard form and in a daunorubicin-resistant variant. The researchers found that both vitamin K3 and K5 significantly inhibited the proliferation of both the standard and resistant leukemia cells, suggesting their potential to overcome drug resistance.

Vitamin K Derivatives: A Promising Weapon in the Battle Against Drug Resistance

This research presents vitamin K derivatives, particularly vitamin K3 and K5, as potential agents for overcoming drug resistance in leukemia. The study’s findings suggest that these vitamin derivatives may offer a new therapeutic avenue for treating leukemia, especially in cases where conventional chemotherapy drugs have lost their effectiveness.

Navigating the Shifting Sands of Drug Resistance

Cancer cells can be resilient, adapting to treatments and developing resistance to chemotherapy drugs. This research provides valuable insights into the potential of vitamin K derivatives to overcome drug resistance in leukemia. The study highlights the importance of exploring new therapeutic approaches to combat the ever-evolving landscape of cancer treatment.

Dr.Camel's Conclusion

This study explores the potential of vitamin K3 and K5 to overcome drug resistance in human leukemia cells. The findings suggest that these vitamin derivatives may offer a new therapeutic avenue for treating leukemia, especially in cases where conventional chemotherapy drugs have lost their effectiveness. This research highlights the importance of exploring new therapeutic approaches to combat the ever-evolving landscape of cancer treatment.
Date :
  1. Date Completed 2016-02-16
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

26504027

DOI: Digital Object Identifier

35/11/6041

Related Literature

Article Analysis
・Effects of daunorubicin
SNS
PICO Info
in preparation
Languages

English

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