Paper Details

  1. Home
  2. Paper Details

Protective effects of Ephedra sinica extract on blood-brain barrier integrity and neurological function correlate with complement C3 reduction after subarachnoid hemorrhage in rats.

Author: ChenQianwei, ChenYujie, FengHua, LiQiang, LiWenyan, LiuXin, TangJun, ZhangJohn H, ZhaoHengli, ZuoShilun

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that Ephedra sinica extract protected against early brain injury after subarachnoid hemorrhage in rats by inhibiting complement C3, suggesting a potential therapeutic role for this extract.
Paper Details　
Original Abstract of the Article :
Early brain injury, which is associated with brain cell death, blood-brain barrier disruption, brain edema, and other pathophysiological events, is thought to be the main target in the prevention of poor outcomes after subarachnoid hemorrhage (SAH). Emerging evidences indicates that complement syste...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.neulet.2015.10.056

データ提供：米国国立医学図書館（NLM）

Ephedra Sinica Extract: A Potential Neuroprotective Agent for Subarachnoid Hemorrhage

Subarachnoid hemorrhage (SAH) is a serious medical condition that can lead to significant neurological damage. This research investigates the potential neuroprotective effects of Ephedra sinica extract, a traditional Chinese herbal remedy, in a rat model of SAH. The study explores the extract's ability to protect against blood-brain barrier disruption, brain edema, and neurological dysfunction, identifying its potential mechanism of action.

Ephedra Sinica Extract Shows Promise in Protecting Against SAH-Induced Brain Injury

The study found that Ephedra sinica extract significantly improved neurological function, reduced brain edema, and attenuated blood-brain barrier disruption in rats with SAH. The research identified the inhibition of complement C3, a key component of the immune system, as a potential mechanism underlying the extract's neuroprotective effects.

Exploring Natural Remedies for Brain Injury

This research offers promising insights into the potential of natural remedies for treating SAH and its associated brain injury. The study's findings suggest that Ephedra sinica extract could be a valuable therapeutic agent for preventing neurological complications after SAH.

Dr. Camel's Conclusion

In the quest for effective treatments for subarachnoid hemorrhage, this research has unearthed a potential oasis in the desert of traditional Chinese medicine. The study's findings suggest that Ephedra sinica extract could offer valuable neuroprotective benefits, opening new avenues for exploring natural remedies for brain injury.

Date :
  1. Date Completed 2016-04-15
  2. Date Revised 2020-08-28
Further Info :

Pubmed ID

26518242

DOI: Digital Object Identifier

10.1016/j.neulet.2015.10.056

Related Literature

Article Analysis
・Effective treatment of ephedra
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.