Lorcaserin Reduces the Discriminative Stimulus and Reinforcing Effects of Cocaine in Rhesus Monkeys.

Author: CollinsGregory T, FranceCharles P, GerakLisa R, JavorsMartin A

Paper Details 
Original Abstract of the Article :
Cocaine abuse and obesity are serious public health problems, and studies suggest that both dopamine and serotonin systems are involved in regulating the consumption of drugs and food. Lorcaserin has serotonin (5-HT)2C receptor agonist actions, is approved by the U.S. Food and Drug Administration fo...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702073/

データ提供:米国国立医学図書館(NLM)

Lorcaserin: A Potential Oasis in the Desert of Cocaine Addiction

Cocaine addiction is a serious global health concern, leaving a trail of devastation in its wake. This research delves into the potential of lorcaserin, a medication approved for obesity treatment, to combat cocaine abuse. The researchers conducted a series of experiments using rhesus monkeys, examining the effects of lorcaserin on cocaine's reinforcing and discriminative properties. They used a combination of pharmacological and behavioral methods to assess how lorcaserin interacted with cocaine, exploring its impact on both the rewarding effects and the ability to distinguish cocaine from a placebo. The results revealed that lorcaserin, when administered both acutely and chronically, significantly reduced cocaine-maintained responding in the monkeys, demonstrating its potential to curb cocaine's reinforcing properties. This study provides promising evidence that lorcaserin may offer a novel therapeutic approach to treating cocaine addiction.

A Beacon of Hope in the Desert: Lorcaserin's Potential

The research suggests that lorcaserin may have a dual role in combating cocaine addiction: reducing both the reinforcing effects and the discriminative properties of cocaine. This could be a significant breakthrough in the fight against addiction, as it targets both the rewarding aspects and the ability to recognize the drug. The researchers emphasize the need for further research to confirm these findings and to explore the long-term implications of lorcaserin in treating cocaine addiction.

A New Path Through the Desert of Addiction

While further research is crucial, this study offers a glimmer of hope for those struggling with cocaine addiction. The potential of lorcaserin as a therapeutic agent highlights the ongoing quest to find effective solutions to this complex and challenging problem.

Dr.Camel's Conclusion

This study provides a ray of sunshine in the desert of cocaine addiction. By exploring the potential of a medication already used for obesity, the researchers offer a new path forward in the fight against this devastating disease.

Date :
  1. Date Completed 2016-03-15
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

26534942

DOI: Digital Object Identifier

PMC4702073

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Languages

English

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