Antitumor effects and molecular mechanisms of ponatinib on endometrial cancer cells harboring activating FGFR2 mutations.

Author: KimDo-Hee, KimNam Doo, KwakYeonui, SimTaebo

Paper Details 
Original Abstract of the Article :
Aberrant mutational activation of FGFR2 is associated with endometrial cancers (ECs). AP24534 (ponatinib) currently undergoing clinical trials has been known to be an orally available multi-targeted tyrosine kinase inhibitor. Our biochemical kinase assay showed that AP24534 is potent against wild-ty...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847821/

データ提供:米国国立医学図書館(NLM)

Targeting FGFR2 Mutations in Endometrial Cancer: A New Weapon in the Fight Against Cancer

Endometrial cancer, a type of cancer affecting the lining of the uterus, is like a desert sandstorm, spreading rapidly and threatening the body's health. This research investigates the potential of ponatinib, a targeted therapy, to combat endometrial cancer cells harboring activating FGFR2 mutations, seeking to control the spread of this aggressive disease.

The study found that ponatinib effectively inhibited the growth and spread of endometrial cancer cells with FGFR2 mutations, demonstrating its potential as a promising treatment option. It's like discovering a new and effective weapon in the desert, capable of battling the forces of disease and restoring balance.

Precision Medicine: A Targeted Approach

The study highlights the importance of precision medicine, tailoring treatments to the specific genetic makeup of cancer cells. It's like a desert scout, carefully identifying the enemy's weaknesses and strategizing the most effective approach to combat them.

Hope for Endometrial Cancer Patients

This research offers hope for patients with endometrial cancer, demonstrating the potential of targeted therapies to effectively combat this challenging disease. It's like finding a hidden oasis in the desert, providing a source of hope and a path towards recovery.

Dr.Camel's Conclusion

This research offers a promising new approach to treating endometrial cancer, targeting the specific genetic mutations that drive the disease's growth. It's like discovering a new and effective weapon in the fight against cancer, offering hope for a more successful outcome.

Date :
  1. Date Completed 2016-10-31
  2. Date Revised 2020-09-30
Further Info :

Pubmed ID

26574622

DOI: Digital Object Identifier

PMC4847821

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Languages

English

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