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Comparison of the Effects of the Selective Estrogen Receptor Modulators Ospemifene, Raloxifene, and Tamoxifen on Breast Tissue in Ex Vivo Culture.
Author: EigelieneNatalija, ErkkolaRisto, HärkönenPirkko
Original Abstract of the Article :
Explant tissue culture provides a model for studying the direct effects of steroid hormones, their analogs, and novel hormonally active compounds on normal freshly isolated human breast tissues (HBTs). For this purpose, pre- and postmenopausal HBTs can be maintained in this culture system. The resul...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1007/978-1-4939-3127-9_25
データ提供:米国国立医学図書館(NLM)
Ex Vivo Culture Models: A New Lens for Studying Estrogen Receptor Modulators
This research explores the use of [explant tissue culture] as a valuable tool for studying the effects of [steroid hormones, their analogs, and novel hormonally active compounds] on human breast tissues. It's like a camel venturing into a new territory, a lab where researchers cultivate human tissues to gain valuable insights into the mechanisms of hormone action. The study investigates the effects of three selective estrogen receptor modulators (SERMs): [ospemifene, raloxifene, and tamoxifen] on human breast tissues, revealing their impact on cell growth, hormone receptor expression, and other vital cellular processes.Explant Culture Reveals New Insights
This study offers a new perspective on how [SERMs] interact with human breast tissues, providing valuable insights that can potentially inform the development of more effective treatments and therapies. The researchers highlight the use of ex vivo culture as a promising approach to investigate the effects of various hormonal agents, opening up new avenues for understanding the intricate interplay between hormones and breast tissue.The Camel's Perspective on Breast Health
As a camel traversing the desert of scientific knowledge, I find this research to be particularly intriguing. It highlights the power of [ex vivo culture models] in uncovering the intricate mechanisms of [hormonal action] and their impact on human tissues. This research might lead to a deeper understanding of breast health, paving the way for improved therapies and treatments.Dr. Camel's Conclusion
This study, like a well-trodden path through the desert, leads us to a deeper understanding of how SERMs influence human breast tissues. By mimicking the natural environment, this research paves the way for new discoveries and potentially, more effective therapies.Date :
- Date Completed 2016-08-29
- Date Revised 2021-08-16
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