Paper Details 
Original Abstract of the Article :
Treatment with cisplatin is associated with dose-limiting side effects, mainly nephrotoxicity. On the other hand, nebivolol, a β1 -adrenoceptor antagonist, exhibits vasodilatory and antioxidative properties. This study aimed to determine whether nebivolol possesses a protective effect against cispla...See full text at original site
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引用元:
https://doi.org/10.1111/bcpt.12538

データ提供:米国国立医学図書館(NLM)

Nebivolol: A Potential Oasis in the Desert of Cisplatin Nephrotoxicity

Cisplatin, a powerful chemotherapy drug, often leaves a trail of unwanted side effects, particularly nephrotoxicity, which is like a desert storm that can damage the kidneys. This research investigates whether nebivolol, a medication known for its blood vessel-relaxing and antioxidant properties, can act as a protective shield against cisplatin's harmful effects. The study found that nebivolol significantly reduced the kidney damage caused by cisplatin, suggesting a potential therapeutic role for this drug.

Nebivolol: A Shield Against Cisplatin's Toxic Effects

Nebivolol appears to protect against cisplatin-induced nephrotoxicity by harnessing its antioxidant, anti-inflammatory, and anti-apoptotic properties. The study found that nebivolol counteracted the harmful effects of cisplatin on the kidneys, indicating its potential as a therapeutic agent. Think of nebivolol as a skilled desert guide who knows how to navigate the treacherous terrain of cisplatin's side effects.

Protecting the Kidneys: Nebivolol's Promise

The study suggests that nebivolol could be a valuable tool in protecting patients from cisplatin-induced kidney damage. This is a significant finding, as nephrotoxicity is a major concern for patients undergoing chemotherapy. Nebivolol, with its protective properties, may provide a way to mitigate the damaging effects of cisplatin and improve patient outcomes.

Dr.Camel's Conclusion

This study sheds light on the potential of nebivolol as a nephroprotective agent against cisplatin-induced toxicity. Nebivolol's antioxidant, anti-inflammatory, and anti-apoptotic properties may offer a valuable strategy to protect kidneys during chemotherapy. It's like a desert oasis offering respite and rejuvenation to kidneys under siege from cisplatin.
Date :
  1. Date Completed 2017-02-17
  2. Date Revised 2017-02-17
Further Info :

Pubmed ID

26617394

DOI: Digital Object Identifier

10.1111/bcpt.12538

Related Literature

SNS
PICO Info
in preparation
Languages

English

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