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The Effects of Chlorpromazine on Reproductive System and Function in Female Rats.

Author: AhmadiAbbas, MovahedElham, SadrkhanlouRajabali, ZamaniZahra, ZareSamad

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Chlorpromazine (CPZ) is an antipsychotic drug that can lead to sexual dysfunction by increasing prolactin levels. This study evaluated the effects of CPZ-induced hyperprolactinemia on ovarian follicular growth, gonadotropins, and ovarian source hormones. CPZ-treated animals showed increased ovarian dysfunction, atretic follicles, and reduced pregnancy rates. These effects were dose-dependent, suggesting that CPZ-induced disturbances are related to the level of prolactin, which is largely dose-dependent.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Chlorpromazine (CPZ), an antipsychotic drug, is associated with increased risk of sexual dysfunction through increasing prolactin levels. The current study evaluates the effect of CPZ-induced hyperprolactinemia on ovarian follicular growth, gonadotropins, and alteration of ovarian source...See full text at original site
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引用元：
https://doi.org/10.22074/ijfs.2015.4553

データ提供：米国国立医学図書館（NLM）

Chlorpromazine - A Double-Edged Sword for Female Reproductive Health

This study investigates the effects of chlorpromazine (CPZ), an antipsychotic drug, on the reproductive system of female rats. The researchers found that CPZ administration significantly increased prolactin levels, leading to a dose-dependent disruption of ovarian follicular growth and alterations in gonadotropin and ovarian hormone levels. The study highlights the potential for CPZ to negatively impact female reproductive health, particularly through its effects on ovarian function.

CPZ - A Potential Disruptor of Ovarian Function

The study's findings demonstrate the potential for CPZ to disrupt ovarian function, leading to a decline in follicular growth and alterations in hormone levels. This underscores the need for careful consideration of the potential reproductive side effects of CPZ in women, particularly those of reproductive age. This research also highlights the importance of monitoring prolactin levels in patients undergoing CPZ treatment to detect any potential adverse effects on ovarian function.

CPZ - A Reminder to Consider the Wider Impact

This study reminds us that even medications intended for specific conditions can have unintended effects on other systems, particularly the delicate balance of the reproductive system. Think of CPZ as a desert wind that can disrupt the delicate ecosystem of the ovaries. This research encourages a holistic approach to healthcare, considering the potential impact of medications on various systems and prioritizing patient well-being.

Dr. Camel's Conclusion

This study serves as a reminder of the complex interplay between medications and the body's delicate systems. CPZ, while effective for treating certain conditions, can have significant effects on female reproductive health. This research underscores the need for careful consideration of the potential side effects of medications and for a holistic approach to patient care.

Date :
  1. Date Completed 2015-12-08
  2. Date Revised 2020-09-29
Further Info :

Pubmed ID

26644861

DOI: Digital Object Identifier

10.22074/ijfs.2015.4553

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PICO Info
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Languages

English

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