TPMT and ITPA genetic variants in Lithuanian inflammatory bowel disease patients: Prevalence and azathioprine-related side effects.

Author: DenapieneGoda, JonaitisLaimas, KiudelisGediminas, KupcinskasJuozas, KupcinskasLimas, SkiecevicieneJurgita, SteponaitieneRuta, SurvilaiteSanta, ValantinasJonas, VarkalaiteGreta

Paper Details 
Original Abstract of the Article :
Inter-individual thiopurine metabolism variability can influence treatment outcomes in inflammatory bowel disease (IBD) patients. Genetic polymorphisms in thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) were linked with toxicity of azathioprine (AZA). The aim of t...See full text at original site
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引用元:
https://doi.org/10.1016/j.advms.2015.09.008

データ提供:米国国立医学図書館(NLM)

Personalized Medicine: Tailoring Treatment for IBD

Inflammatory bowel disease (IBD), a chronic condition affecting the digestive system, can significantly impact a patient's quality of life. Finding the right treatment for IBD often requires a personalized approach, considering individual patient factors, including genetic predisposition.

This research explores the role of genetic polymorphisms in thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) in Lithuanian IBD patients, analyzing their association with azathioprine (AZA)-related side effects. The study highlights the potential for using genetic information to optimize AZA treatment for IBD patients, minimizing the risk of adverse events. Think of it as a desert expedition where understanding the terrain, including potential hazards, is crucial for a successful journey.

Optimizing Treatment: The Power of Genetics

This research highlights the potential of personalized medicine in improving IBD treatment outcomes. It emphasizes the importance of considering genetic factors to optimize treatment regimens and minimize the risk of adverse events.

Managing IBD: The Importance of Collaboration

This research underscores the importance of close collaboration between healthcare professionals and IBD patients. Working together to understand individual needs and tailoring treatment accordingly is essential for achieving optimal patient outcomes.

Dr. Camel's Conclusion

The desert of IBD treatment is a complex and challenging landscape. This research offers a valuable oasis – personalized medicine, where genetic information can guide treatment decisions and improve patient outcomes. By embracing a collaborative approach and utilizing the power of genetics, we can help IBD patients navigate this challenging terrain more effectively.
Date :
  1. Date Completed 2017-01-09
  2. Date Revised 2018-12-11
Further Info :

Pubmed ID

26674571

DOI: Digital Object Identifier

10.1016/j.advms.2015.09.008

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SNS
PICO Info
in preparation
Languages

English

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