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Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1.

Author: BuGuojun, KanekiyoTakahisa, LiuChia-Chen, RogersJustin, ShinoharaMitsuru, TachibanaMasaya, YamazakiYu

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effects of bexarotene, a drug that activates a specific receptor, on synapse loss in aging mice. Bexarotene was effective in preventing synapse loss, but it also had toxic side effects.
Paper Details　
Original Abstract of the Article :
Apolipoprotein E (apoE) plays a critical role in maintaining synaptic integrity by transporting cholesterol to neurons through the low-density lipoprotein receptor related protein-1 (LRP1). Bexarotene, a retinoid X receptor (RXR) agonist, has been reported to have potential beneficial effects on cog...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/26688581

データ提供：米国国立医学図書館（NLM）

Bexarotene: A Potential Oasis in the Desert of Aging-Related Synapse Loss

The aging process is like a vast desert, where synapses, the connections between neurons, gradually disappear. This study explores the potential of bexarotene, a retinoid X receptor (RXR) agonist, to combat age-related synapse loss. Using [研究手法], the researchers investigated the effects of bexarotene on synapse loss in mice. They found that bexarotene [主要な発見] in the brains of control mice. However, the study also reveals that bexarotene [特筆すべき結果や意義], suggesting that its therapeutic application requires caution due to its potential side effects.

Bexarotene: A Double-Edged Sword for Aging-Related Synapse Loss

The study findings suggest that bexarotene [社会的な意義] in combating age-related synapse loss. However, the study also highlights the potential risks associated with bexarotene treatment, emphasizing the need for careful consideration of the potential benefits and risks before using this drug.

Bexarotene: A Potential Solution with Cautious Optimism

The study highlights the potential benefits of bexarotene in combating age-related synapse loss. [健康的なベネフィットもしくはリスク] Further research is needed to develop safer and more effective strategies for targeting apoE pathways in the brain to mitigate age-related cognitive decline.

Dr.Camel's Conclusion

The desert of aging presents numerous challenges, including synapse loss. This study offers a glimpse of hope with bexarotene's potential to restore synaptic integrity. However, the study also underscores the importance of considering the potential risks associated with this drug. As we journey through the desert of aging, it's crucial to be mindful of both the potential benefits and the potential pitfalls of different interventions.

Date :
  1. Date Completed 2016-06-27
  2. Date Revised 2020-12-09
Further Info :

Pubmed ID

26688581

DOI: Digital Object Identifier

NIHMS747283

Related Literature

Article Analysis
・Side Effects of bexarotene
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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