Harpagophytum Procumbens Ethyl Acetate Fraction Reduces Fluphenazine-Induced Vacuous Chewing Movements and Oxidative Stress in Rat Brain.

Author: BoligonAline Augusti, BusanelloAlcindo, Chiapinotto CerettaAna Paula, FachinettoRoselei, KrumBárbara Nunes, PerozaLuis Ricardo, SchafferLarissa Finger, SudatiJéssie Haigert, WagnerCaroline, de FreitasCatiuscia Molz, de Moraes ReisElizete

Paper Details 
Original Abstract of the Article :
Long-term treatment with fluphenazine is associated with manifestation of extrapyramidal side effects, such as tardive dyskinesia. The molecular mechanisms related to the pathophysiology of TD remain unclear, and several hypotheses, including a role for oxidative stress, have been proposed. Harpagop...See full text at original site
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引用元:
https://doi.org/10.1007/s11064-015-1811-y

データ提供:米国国立医学図書館(NLM)

Harpagophytum procumbens: A potential treatment for fluphenazine-induced orofacial dyskinesia

In the vast desert of medical research, scientists are constantly searching for oases of solutions to complex health problems. This study delves into the potential of a natural remedy, Harpagophytum procumbens, for treating a distressing side effect of the antipsychotic medication fluphenazine. Fluphenazine, while effective in managing certain mental health conditions, can sometimes trigger involuntary movements of the face and mouth, a condition known as orofacial dyskinesia. The authors investigated whether Harpagophytum procumbens, a plant known for its anti-inflammatory properties, could alleviate these debilitating movements. Using a series of experiments in rats, they meticulously assessed the effects of this natural remedy on behavior, biochemical markers, and oxidative stress. Their findings suggest that Harpagophytum procumbens holds promise as a potential therapeutic agent for managing the involuntary movements associated with fluphenazine treatment.

Harpagophytum procumbens: An oasis of hope in the desert of dyskinesia

The results of this study, like a refreshing spring in the desert, offer a glimmer of hope for individuals struggling with fluphenazine-induced orofacial dyskinesia. Harpagophytum procumbens, with its ability to reduce involuntary movements and oxidative stress, presents a promising avenue for alleviating this distressing side effect. Further research is needed to confirm its effectiveness in humans, but this study paves the way for the development of natural therapies to complement conventional treatments.

Natural remedies: A harmonious blend of tradition and science

As we navigate the complexities of modern medicine, it's important to appreciate the wisdom of traditional remedies. Harpagophytum procumbens, with its long history of use in traditional medicine, now finds itself at the forefront of scientific research. This study highlights the potential of harnessing the power of nature to address health challenges. Just as camels have adapted to survive in the harsh desert environment, we can learn from nature's wisdom to create more effective and holistic approaches to health.

Dr.Camel's Conclusion

This research, like a caravan traversing the desert, has uncovered a potential solution for a troublesome side effect of fluphenazine. Harpagophytum procumbens, with its ability to combat oxidative stress and reduce involuntary movements, offers hope for a more comfortable and manageable treatment experience. This study reminds us that even in the face of adversity, nature's bounty can provide solace and healing.

Date :
  1. Date Completed 2016-12-13
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

26732278

DOI: Digital Object Identifier

10.1007/s11064-015-1811-y

Related Literature

SNS
PICO Info
in preparation
Languages

English

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