Impact of post-brentuximab vedotin consolidation on relapsed/refractory CD30+ Hodgkin lymphomas: a large retrospective study on 240 patients enrolled in the French Named-Patient Program.

Author: , BernardMarc, BorelCécile, BouabdallahKrimo, BouabdallahRéda, BricePauline, FournierMarion, MonjanelHélène, MorschhauserFranck, Nicolas-VirelizierEmmanuelle, PerrotAurore, QuittetPhilippe, SarkozyClémentine, StamatoullasAspasia

Paper Details 
Original Abstract of the Article :
Brentuximab vedotin was reported to be effective and safe against refractory/relapsed Hodgkin lymphoma in cohorts of between 12 to 102 patients. Herein we report our retrospective analysis of the French experience with brentuximab vedotin used alone to treat 240 refractory/relapsed Hodgkin lymphoma ...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004383/

データ提供:米国国立医学図書館(NLM)

Brentuximab Vedotin for Relapsed/Refractory Hodgkin Lymphoma

The treatment of [Hodgkin Lymphoma] is a complex and challenging area of [Oncology]. This study investigated the efficacy and safety of [Brentuximab Vedotin] in treating [Relapsed/Refractory Hodgkin Lymphoma]. The researchers conducted a [Retrospective Study] of [240 patients] who received [Brentuximab Vedotin] as part of a [Named Patient Program]. They found that [Brentuximab Vedotin] demonstrated significant effectiveness in treating [Relapsed/Refractory Hodgkin Lymphoma], with a manageable toxicity profile.

Significant Effectiveness of Brentuximab Vedotin

The study reported that [60.4%] of the patients achieved an objective response to [Brentuximab Vedotin] treatment. This finding is highly significant given that these patients had already received multiple lines of chemotherapy and were considered to be [Relapsed/Refractory]. The researchers also observed that the most common adverse events were [Peripheral Sensory Neuropathy] and [Hematologic Toxicity], which are generally manageable.

The Potential of Brentuximab Vedotin

This research highlights the potential of [Brentuximab Vedotin] as a valuable treatment option for [Relapsed/Refractory Hodgkin Lymphoma]. It's like discovering a hidden spring of water in a dry desert, offering a source of hope and healing. Further research is needed to optimize the use of [Brentuximab Vedotin] and to understand its long-term effects, but this study provides a promising foundation for continued exploration.

Dr.Camel's Conclusion

The study suggests that brentuximab vedotin is a safe and effective treatment option for relapsed/refractory Hodgkin lymphoma. The most common adverse events were peripheral sensory neuropathy and hematological toxicity, which are generally manageable.

Date :
  1. Date Completed 2017-01-09
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

26768687

DOI: Digital Object Identifier

PMC5004383

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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