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Effects of Silodosin and Tamsulosin on the Seminal Vesicle Contractile Response.

Author: HayashiTokumasa, MatsuokaKei, NakamuraKei-ichiro, TakeyaMitsue

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

The initial contractions triggered by neuronal excitations were suppressed by silodosin and tamsulosin, suggesting that the ejaculation dysfunction may be attributed to the α1A-AR antagonist-mediated suppression of nerve-evoked contractions in the seminal vesicle.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: To understand the mechanisms underlying ejaculation dysfunction caused by α1A-adrenocetor (AR) antagonists, the effects of α1A-AR antagonists on the contractile responses of the seminal vesicle were investigated. METHODS: Isolated seminal vesicles from guinea pigs were cannulated and pr...See full text at original site
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引用元：
https://doi.org/10.1111/luts.12072

データ提供：米国国立医学図書館（NLM）

Unraveling the Mystery of Ejaculation Dysfunction: A Look at Alpha1A-Adrenergic Receptor Antagonists

Ejaculation dysfunction, a common concern for men, can be a source of frustration and distress. This study explores the potential role of α1A-adrenergic receptor (AR) antagonists, like silodosin and tamsulosin, in causing ejaculation dysfunction. The researchers investigate the effects of these antagonists on the contractile responses of the seminal vesicle, a crucial organ involved in the ejaculatory process. Their findings suggest that α1A-AR antagonists may suppress nerve-evoked contractions in the seminal vesicle, potentially leading to ejaculation dysfunction.

The Role of α1A-Adrenergic Receptor Antagonists in Ejaculation

The study reveals a potential mechanism for ejaculation dysfunction induced by α1A-AR antagonists. By suppressing nerve-evoked contractions in the seminal vesicle, these antagonists may disrupt the normal ejaculatory process. These findings are significant because they provide valuable insights into the potential side effects of these commonly used medications.

Navigating the Side Effects of Medications

Understanding the potential side effects of medications is essential for informed healthcare decisions. This study highlights the importance of considering the impact of α1A-AR antagonists on ejaculation function, especially in patients who are concerned about this aspect of their health. Open communication with your healthcare provider is crucial to ensure that treatment decisions are made with awareness of all potential side effects.

Dr.Camel's Conclusion

Think of the seminal vesicle as a bustling marketplace in a desert oasis. α1A-AR antagonists, like silodosin and tamsulosin, act as unexpected visitors, disrupting the marketplace's usual rhythm and flow. This study illuminates the potential consequences of this disruption, providing a better understanding of how these medications might affect ejaculation function.

Date :
  1. Date Completed 2016-12-13
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

26789544

DOI: Digital Object Identifier

10.1111/luts.12072

Related Literature

Article Analysis
・Effects of silodosin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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