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A High-Affinity Native Human Antibody Disrupts Biofilm from Staphylococcus aureus Bacteria and Potentiates Antibiotic Efficacy in a Mouse Implant Infection Model.

Author: EllsworthStote, EstellésAngeles, GremmelmaierNina Khanna, HeideckerManfred, KauvarLawrence M, LeightonAnton, LiuKeyi, LomongsodEvelene, NguyenDa, RyserStefan, SimonReyna J, StephensonRobert, TenorioEdgar, WoischnigAnne-Kathrin, YangYifan, ZhangJianzhong

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

TRL1068, a human monoclonal antibody, can disrupt established biofilms and may be a promising candidate for combination therapy with antibiotics to treat bacterial infections.
Paper Details　
Original Abstract of the Article :
Many serious bacterial infections are difficult to treat due to biofilm formation, which provides physical protection and induces a sessile phenotype refractory to antibiotic treatment compared to the planktonic state. A key structural component of biofilm is extracellular DNA, which is held in plac...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808150/

データ提供：米国国立医学図書館（NLM）

TRL1068: A Potential Breakthrough in Treating Biofilm-Forming Infections

Biofilm formation is a major challenge in treating bacterial infections. It creates a protective barrier that makes bacteria resistant to antibiotics. This study investigated the potential of a novel human monoclonal antibody, TRL1068, to disrupt biofilms and enhance antibiotic efficacy.

The researchers found that TRL1068, targeting DNABII proteins involved in biofilm formation, disrupted established biofilms in vitro and significantly reduced bacterial counts in a mouse implant infection model when combined with daptomycin.

TRL1068: A Promising Strategy for Combating Biofilm Infections

The study suggests that TRL1068 could be a valuable tool in treating biofilm-forming infections. The antibody's ability to disrupt biofilms and enhance antibiotic efficacy offers a promising strategy for addressing this challenging aspect of bacterial infections.

New Hope for Treating Difficult Infections

Finding effective treatments for biofilm-forming infections can feel like searching for a hidden oasis in a desert of resistance. This study offers a glimmer of hope, highlighting the potential of TRL1068 to disrupt biofilms and improve the effectiveness of antibiotics.

Dr.Camel's Conclusion

This study is like a camel caravan discovering a new route through the desert of antibiotic resistance. TRL1068 offers a promising solution for breaking through the protective barrier of biofilms, paving the way for more effective treatment of infections.

Date :
  1. Date Completed 2016-12-13
  2. Date Revised 2020-12-15
Further Info :

Pubmed ID

26833157

DOI: Digital Object Identifier

PMC4808150

Related Literature

Article Analysis
・Effects of daptomycin injection
SNS
PICO Info
in preparation
Languages

English

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