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Global Urine Metabolomics in Patients Treated with First-Line Tuberculosis Drugs and Identification of a Novel Metabolite of Ethambutol.
Author: AryaRakesh, BishwalSubasa Chandra, DasAnjan, DasMrinal Kumar, DebnathRahul, DebnathSanjita, LodhAnindita, NandaRanjan Kumar
Original Abstract of the Article :
Population level variation of drug metabolism phenotype (DMP) has great implications in treatment outcome, drug-related side effects, and resistance development. In this study, we used a gas chromatography-time of flight-mass spectrometry (GC-TOF-MS)-based untargeted urine metabolomics approach to u...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808164/
データ提供:米国国立医学図書館(NLM)
Unveiling the Metabolic Landscape of Tuberculosis Treatment: A Journey Through Urine Metabolomics
This study explores the metabolic responses of patients undergoing treatment for tuberculosis (TB) using a cutting-edge technique called urine metabolomics. Imagine a camel caravan navigating through a challenging terrain, where the journey can leave a unique metabolic footprint. Urine metabolomics is like a powerful tool that allows us to analyze these metabolic changes, providing valuable insights into the individual responses to treatment.
Metabolic Clues: Understanding Patient Responses to TB Treatment
The study uses urine metabolomics to identify the metabolic pathways involved in the breakdown of anti-TB drugs and their associated metabolites. This information can help us understand how different patients metabolize these drugs, potentially predicting individual responses to treatment and the risk of side effects. It's like a caravan studying the tracks left behind by its members, revealing individual differences in how they traverse the terrain.
A Deeper Understanding of Drug Metabolism
This study sheds light on the complex processes of drug metabolism in TB patients, highlighting the importance of individualized treatment approaches. It's like a caravan recognizing that each camel has unique needs and responses to the journey, requiring a tailored approach to ensure their well-being.
Dr. Camel's Conclusion
This research is a testament to the power of metabolomics to understand the individual responses to treatment, paving the way for more personalized and effective TB therapies. It's like a caravan learning to read the desert landscape, using the clues left behind to navigate its journey more effectively.
Date :
- Date Completed 2016-12-13
- Date Revised 2018-11-13
Further Info :
Related Literature
English
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