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In vitro synergistic effects of chlorpromazine and sertraline in combination with amphotericin B against Cryptococcus neoformans var. grubii.

Author: AlvesSydney H, ChassotFrancieli, LoretoÉrico S, RossatoLuana, SanturioJanio M, ZanetteRégis A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Chlorpromazine and sertraline may have synergistic effects with amphotericin B in treating neurocryptococcosis.
Paper Details　
Original Abstract of the Article :
Cryptococcus neoformans is encapsulated yeast that causes cryptococcosis. The cryptococcal meningitis may cause neuropsychiatric symptoms. Here, we evaluated the in vitro activity of amphotericin B (AMB), chlorpromazine (CLOR), and sertraline (SERT) alone or in combination against clinical isolates ...See full text at original site
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引用元：
https://doi.org/10.1007/s12223-016-0449-8

データ提供：米国国立医学図書館（NLM）

Combating Cryptococcosis: A Synergistic Approach with Chlorpromazine and Sertraline

Cryptococcus neoformans is an encapsulated yeast that can cause cryptococcosis, a potentially life-threatening infection. This study investigates the in vitro activity of amphotericin B (AMB), chlorpromazine (CLOR), and sertraline (SERT) alone and in combination against clinical isolates of C. neoformans. The researchers aim to identify potential synergistic drug combinations that could enhance the effectiveness of antifungal treatment.

Synergistic Effects: A Potential Breakthrough in Cryptococcosis Treatment

The study demonstrates a synergistic effect when combining CLOR or SERT with AMB against C. neoformans. The findings suggest that these drug combinations could enhance the antifungal activity of AMB, potentially improving treatment outcomes for patients with cryptococcosis. This research could lead to the development of new and more effective treatment strategies for this challenging infection.

Cryptococcosis Management: Exploring New Treatment Avenues

This study, like a caravan searching for a new route through the desert of cryptococcosis treatment, explores the potential of drug combinations to enhance antifungal efficacy. The findings suggest that combining CLOR or SERT with AMB could offer a promising approach to managing this challenging infection. The research opens new avenues for developing more effective and personalized treatment strategies for patients with cryptococcosis.

Dr.Camel's Conclusion

This research, like a desert oasis offering hope and rejuvenation, reveals a potential breakthrough in the treatment of cryptococcosis. The synergistic effect of combining CLOR or SERT with AMB provides a new and promising approach to combating this challenging infection. It's a testament to the power of collaborative research in finding innovative solutions to complex medical problems.

Date :
  1. Date Completed 2017-02-10
  2. Date Revised 2022-03-10
Further Info :

Pubmed ID

26847460

DOI: Digital Object Identifier

10.1007/s12223-016-0449-8

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Languages

English

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