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C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins.

Author: AndersonEdward N, CorkinsMark E, DimitriadiMaria, HartAnne C, HuangHuiyan, LiJia-Cheng, ParsonsSadé, SinclairDavid A, SinghKomudi, SorkaçAltar, TuceyTim M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

FUdR, an inhibitor of thymidylate synthase, can activate stress response pathways and extend lifespan in Caenorhabditis elegans under hypertonic stress conditions, but this finding may require re-interpretation of lifespan studies using FUdR.
Paper Details　
Original Abstract of the Article :
Moderate stress can increase lifespan by hormesis, a beneficial low-level induction of stress response pathways. 5'-fluorodeoxyuridine (FUdR) is commonly used to sterilize Caenorhabditis elegans in aging experiments. However, FUdR alters lifespan in some genotypes and induces resistance to thermal a...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/26854551

データ提供：米国国立医学図書館（NLM）

Unlocking the Secrets of Lifespan Extension: A Tale of Stress and FUdR

This study delves into the intriguing world of lifespan extension in the nematode worm, C. elegans. The authors explore the role of osmotic stress and the drug FUdR in promoting longevity, uncovering a complex interplay between stress, gene expression, and lifespan.

A Desert Oasis of Longevity: FUdR and Osmotic Stress

This study reveals a surprising finding: the combination of hypertonic stress and FUdR treatment significantly extends the lifespan of C. elegans. This unexpected result highlights the potential of FUdR, often used to sterilize worms, to activate stress response pathways, promoting longevity.

Navigating the Desert of Aging: Understanding the Mechanisms

This research offers valuable insights into the mechanisms behind lifespan extension. The authors demonstrate that FUdR, through its inhibition of thymidylate synthase, activates stress response pathways, leading to increased expression of DAF-16 FOXO and other longevity-associated genes. This study underscores the complex interplay between stress, gene expression, and lifespan, offering promising avenues for future research in aging and longevity.

Dr. Camel's Conclusion

This study provides a fascinating glimpse into the mechanisms behind lifespan extension, revealing a potential link between stress, gene expression, and longevity. Just as a camel navigates the harsh desert environment, we must carefully consider the interplay of various factors when seeking to extend lifespan. This research encourages us to explore the potential of stress-induced responses and targeted therapies to promote longevity and improve human health.

Date :
  1. Date Completed 2016-12-13
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

26854551

DOI: Digital Object Identifier

NIHMS762151

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Languages

English

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