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Toxic effects of melphalan, topotecan and carboplatin on retinal pigment epithelial cells.

Author: AisenbreySabine, HagemannUlrike, JanuschowskiKai, SchnichelsSven, SchraderMerle, SüsskindDaniela

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Melphalan, topotecan, and carboplatin, commonly used chemotherapeutic drugs for retinoblastoma, showed direct toxic effects on retinal pigment epithelium (RPE) cells in a cell culture model. This suggests that these drugs may contribute to RPE alterations observed in some retinoblastoma patients.
Paper Details　
Original Abstract of the Article :
PURPOSE: Clinical evidence of retinal pigment epithelium (RPE) alterations after intra-arterial (IAC) and intravitreal chemotherapy (IViC) of retinoblastoma has been reported. We, therefore, investigated the cellular toxic effects of melphalan, topotecan and carboplatin on the RPE in a cell culture ...See full text at original site
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引用元：
https://doi.org/10.1111/aos.12990

データ提供：米国国立医学図書館（NLM）

The Impact of Chemotherapy on Retinal Pigment Epithelial Cells: A Cautionary Tale

Retinoblastoma is a type of cancer that affects the eye. Chemotherapy is often used to treat this condition, but it can have side effects on other parts of the eye, particularly the retinal pigment epithelium (RPE). This study investigates the toxic effects of three chemotherapy drugs: melphalan, topotecan, and carboplatin, on RPE cells in a laboratory setting.

Chemotherapy's Impact on Retinal Pigment Epithelial Cells: A Balancing Act

The study found that melphalan, topotecan, and carboplatin can have a direct toxic effect on RPE cells. This research highlights the potential for these drugs to damage the RPE, which could lead to vision problems. This information is as vital as a well-stocked caravan, ensuring that healthcare providers are aware of the potential risks and benefits of chemotherapy for retinoblastoma.

Treating Retinoblastoma: A Delicate Dance

Retinoblastoma treatment requires a delicate balance between eradicating the cancer and preserving vision. This study's findings emphasize the importance of considering the potential side effects of chemotherapy on the RPE. It's a reminder that managing complex diseases often involves navigating challenging trade-offs, much like a camel adapting to the ever-changing landscape of a desert.

Dr.Camel's Conclusion

Retinoblastoma is a challenging condition that requires careful management. This study highlights the potential toxic effects of chemotherapy drugs on the RPE. It's a reminder that treatment decisions must be made with a thorough understanding of both the benefits and risks, much like a skilled caravan leader navigating a vast and potentially dangerous desert.
Date :
  1. Date Completed 2017-01-09
  2. Date Revised 2022-03-21
Further Info :

Pubmed ID

26893290

DOI: Digital Object Identifier

10.1111/aos.12990

Related Literature

Article Analysis
・Effects of topotecan・Effects of melphalan
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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