Use of cinacalcet for the management of hyperparathyroidism in patients with different degrees of renal failure.

Author: BravoJuan, CastillaYina A, EstebanMaría A, EstebanRafael J, Fernández-CastilloRafael, García-ValverdeMaría, Nozal-FernándezGonzalo, OrellanaJosé M

Paper Details 
Original Abstract of the Article :
BACKGROUND: The effects of cinacalcet in persistent and/or hypercalcaemia-associated secondary hyperparathyroidism (SHPT) have been described in patients on dialysis. OBJECTIVES: To evaluate the efficacy and safety of cinacalcet in SHPT not on dialysis and its effects on bone turnover markers. MET...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1016/j.nefro.2015.10.017

データ提供:米国国立医学図書館(NLM)

Cinacalcet: A New Oasis for Hyperparathyroidism in CKD

Chronic kidney disease (CKD) often leads to secondary hyperparathyroidism (SHPT), a condition marked by elevated parathyroid hormone (PTH) levels. This study explores the efficacy and safety of cinacalcet, a calcimimetic drug, in managing SHPT in patients with varying degrees of CKD, including those not on dialysis. The researchers analyzed data from a longitudinal, observational study of CKD patients with SHPT, evaluating the impact of cinacalcet on PTH levels, calcium levels, and bone turnover markers. They found that cinacalcet, even at low doses, effectively reduced PTH and calcium levels in patients with SHPT who were not on dialysis, without causing significant side effects or affecting renal function. This study sheds light on the potential of cinacalcet as a valuable therapeutic option for managing SHPT in CKD patients, offering a beacon of hope for improving their health outcomes.

Cinacalcet: A Light in the Darkness of SHPT

The findings of this study suggest that cinacalcet can be an effective treatment option for managing SHPT in CKD patients, even those who are not on dialysis. The drug effectively lowers PTH and calcium levels, improving overall health and potentially mitigating the progression of CKD. This research offers valuable insights into the potential of cinacalcet as a therapeutic strategy for SHPT, providing hope for improving the lives of CKD patients.

Cinacalcet: A Promising Solution for CKD Patients

This research highlights the importance of exploring new treatment options for CKD patients with SHPT. Cinacalcet, a calcimimetic drug, has emerged as a promising solution for managing this condition, effectively reducing PTH and calcium levels without causing significant side effects. This study encourages further investigation into the use of cinacalcet in CKD patients, particularly those not on dialysis, to improve their health and quality of life.

Dr.Camel's Conclusion

This study is a refreshing oasis in the vast desert of CKD research, highlighting the potential of cinacalcet as a valuable tool for managing SHPT. The findings suggest that cinacalcet can effectively reduce PTH and calcium levels, improving overall health and potentially mitigating the progression of CKD. This research encourages further investigation into the use of cinacalcet as a therapeutic strategy for SHPT, offering hope for a brighter future for CKD patients.

Date :
  1. Date Completed 2017-09-28
  2. Date Revised 2022-04-10
Further Info :

Pubmed ID

26906451

DOI: Digital Object Identifier

10.1016/j.nefro.2015.10.017

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.