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Antihypertensive nano-ceuticales based on chitosan biopolymer: Physico-chemical evaluation and release kinetics.

Author: ImranMuhammad, ManzoorShahid, NasirHabib, NiazTaskeen, RahmanAbdur, RehmanAsma, ShabbirSaima

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study fabricated antihypertensive nano-ceuticals in hydrophilic carriers of natural origin to improve drugs' solubility, protection, and sustained release.
Paper Details　
Original Abstract of the Article :
Prime risk factor behind cardiovascular associated mortality and morbidity is hypertension. The main challenge with antihypertensive (AHT) drug therapy is their extreme hydrophobic nature and very low oral bio-availability; which result into higher dosage/frequency and associated side effects of dru...See full text at original site
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引用元：
https://doi.org/10.1016/j.carbpol.2016.01.047

データ提供：米国国立医学図書館（NLM）

Developing Antihypertensive Nano-ceuticals for Improved Delivery

This research explores the potential of chitosan-based nanoparticles as a novel delivery system for antihypertensive drugs. The study investigates the physicochemical properties and release kinetics of chitosan nanoparticles loaded with captopril, amlodipine, and valsartan. This innovative approach aims to improve the solubility, protection, and sustained release of these hydrophobic drugs, potentially enhancing their efficacy and reducing side effects.

Improving Drug Delivery and Enhancing Treatment Outcomes

The study demonstrates the successful development of chitosan nanoparticles encapsulating antihypertensive drugs, achieving high encapsulation efficiencies and controlled release profiles. This research suggests that chitosan-based nanoparticles can serve as a promising delivery system for antihypertensive drugs, potentially leading to improved drug bioavailability, reduced dosage requirements, and minimized side effects.

Harnessing Natural Biopolymers for Drug Delivery

This research highlights the potential of natural biopolymers, such as chitosan, in developing innovative drug delivery systems. The study demonstrates the effectiveness of chitosan nanoparticles for encapsulating and delivering antihypertensive drugs, offering a promising alternative to conventional delivery methods. This approach holds potential for improving drug therapy and enhancing patient outcomes.

Dr.Camel's Conclusion

This research, like a resourceful camel utilizing the desert's resources, presents a novel approach for improving the delivery of antihypertensive drugs. By harnessing the power of chitosan-based nanoparticles, researchers have developed a promising delivery system that can enhance drug efficacy, minimize side effects, and improve patient outcomes. This research is a reminder that, just as the desert landscape holds hidden treasures, the field of drug delivery continues to offer innovative solutions for addressing health challenges.

Date :
  1. Date Completed 2016-12-13
  2. Date Revised 2016-12-30
Further Info :

Pubmed ID

26917399

DOI: Digital Object Identifier

10.1016/j.carbpol.2016.01.047

Related Literature

Article Analysis
・Side Effects of captopril
SNS
PICO Info
in preparation
Languages

English

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