Anterior Uveitis Caused by Ocular Side Effects of Afatinib: A Case Report.

Author: IbeTakashi, ItakuraHirotaka, KishiShoji, TodokoroDaisuke

Paper Details 
Original Abstract of the Article :
Afatinib is a second-generation epidermal growth factor receptor (EGFR) inhibitor that has been shown to be effective against EGFR-mutated non-small cell lung cancer (NSCLC) resistant to conventional EGFR inhibitors such as gefitinib and erlotinib. Although ocular side effects of gefitinib and erlot...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772633/

データ提供:米国国立医学図書館(NLM)

Afatinib: A New EGFR Inhibitor with Ocular Side Effects

Afatinib, a [second-generation epidermal growth factor receptor (EGFR) inhibitor], is a valuable treatment option for [EGFR-mutated non-small cell lung cancer (NSCLC)]. However, this case report highlights a rare but serious [ocular side effect] of afatinib therapy: [unilateral iridocyclitis]. The researchers describe the case of a [75-year-old Japanese male] who developed [bilateral conjunctivitis] and subsequently [unilateral granulomatous anterior uveitis] after starting afatinib therapy. The anterior uveitis resolved after [topical medication] and [afatinib washout], but recurred upon restarting the drug. This case underscores the importance of [monitoring patients on afatinib] for [ocular side effects] and being prepared to [adjust treatment] if necessary.

Afatinib: A Double-Edged Sword?

The study highlights the importance of [carefully considering the potential risks and benefits] of afatinib therapy. While it's a [powerful tool] for treating [EGFR-mutated NSCLC], patients and physicians must be aware of its [potential ocular complications].

Eyes Wide Open: Recognizing Ocular Side Effects of Cancer Drugs

This case report serves as a reminder that [cancer treatment] can have [unforeseen side effects], even for seemingly safe drugs. It emphasizes the need for [close monitoring] and [early intervention] when managing patients on [anti-cancer therapies].

Dr.Camel's Conclusion

The case of this patient highlights the complex interplay between [cancer treatment] and [ocular health]. While afatinib is a powerful weapon against [EGFR-mutated NSCLC], it's important to remain vigilant for [ocular side effects] and to [act promptly] when they arise. The desert of cancer treatment can be treacherous, but with careful navigation and a watchful eye, we can help patients navigate their way to a healthier future.

Date :
  1. Date Completed 2016-03-02
  2. Date Revised 2020-09-29
Further Info :

Pubmed ID

26933433

DOI: Digital Object Identifier

PMC4772633

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.