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Delayed yet persistent effects of daily risperidone on activity in developing rats.
Author: BardgettMark E, GannonMatthew A, GriffithMolly S, StevensRachel M
Original Abstract of the Article :
Early-life administration of risperidone, the most widely used antipsychotic drug in children, leads to persistently elevated locomotor activity in adult rats. This study determined whether and when elevated locomotor activity emerges during developmental risperidone administration. Developing and a...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://pubmed.ncbi.nlm.nih.gov/26960160
データ提供:米国国立医学図書館(NLM)
Risperidone's Unexpected Effects on Developing Brains: A Desert Storm
The developing brain is a delicate ecosystem, like a fragile desert oasis, susceptible to disruptions. This study, like a careful expedition into a sensitive environment, investigates the long-term effects of risperidone, an antipsychotic medication, on developing rats. The researchers observed the animals' locomotor activity, a measure of movement, over time, revealing an intriguing pattern.
Risperidone's Hidden Impact: A Delayed Desert Storm
The study found that risperidone initially suppressed locomotor activity in both developing and adult rats, like a calm desert before a storm. However, in developing rats, the effects were delayed, with hyperactivity emerging only later in the treatment period. This delayed response, like a desert storm brewing on the horizon, highlights the unique vulnerability of developing brains to long-term effects of medications.
A Cautionary Tale for Young Minds: Navigating the Desert of Brain Development
This research serves as a reminder of the potential impact of medications on developing brains. It emphasizes the need for careful consideration of long-term effects, especially in young patients. Further research is needed to understand the mechanisms behind these delayed effects and to explore alternative therapeutic strategies that minimize risks to developing brains. This is a critical journey in the desert of neuroscience, where every step must be taken with care and caution.
Dr. Camel's Conclusion
This study, like a beacon in the desert, highlights the complexity of brain development and the need for cautious use of medications in young individuals. The findings underscore the importance of ongoing research to better understand the long-term effects of medications on developing brains.
Date :
- Date Completed 2017-11-08
- Date Revised 2018-11-13
Further Info :
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