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Skin toxicity in BRAF(V600) mutated metastatic cutaneous melanoma patients treated with vemurafenib.

Author: HusznoJoanna, NieckulaJaroslaw, NowaraElzbieta, SlomianGrzegorz

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Vemurafenib treatment was associated with a high incidence of squamous cell carcinoma (38%). The most common cutaneous side effects were hyperkeratotic perifollicular rash (69%) and photosensitivity (15%).
Paper Details　
Original Abstract of the Article :
INTRODUCTION: The use of orally available BRAF kinase inhibitor - vemurafenib is associated with numerous adverse skin reactions. AIM: To assess the safety and early side effects of vemurafenib treatment in the unselected group of patients treated at the outpatient clinic, in particular the assessm...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793055/

データ提供：米国国立医学図書館（NLM）

Vemurafenib and Skin Toxicity: A Case Study in Melanoma Treatment

In the desert of [melanoma treatment], we seek effective therapies while navigating the potential side effects of various medications. This study explores the skin toxicity associated with [vemurafenib], a [BRAF] kinase inhibitor used to treat metastatic cutaneous melanoma.

Assessing Skin Toxicity in Vemurafenib Treatment

The researchers conducted a systematic study of patients treated with vemurafenib, focusing on the incidence of skin toxicity. Their analysis reveals the prevalence of various skin side effects, including hyperkeratotic perifollicular rash and photosensitivity.

Navigating the Skin Toxicity Landscape

This study highlights the importance of careful monitoring for skin toxicity in patients receiving vemurafenib treatment. The findings provide valuable insights for clinicians, helping them to anticipate potential complications and develop appropriate management strategies.

Dr.Camel's Conclusion

In the desert of melanoma treatment, we must be mindful of the potential side effects of our weapons. This study underscores the importance of careful monitoring for skin toxicity in patients receiving vemurafenib, reminding us to navigate the treatment landscape with vigilance and expertise.
Date :
  1. Date Completed 2016-03-17
  2. Date Revised 2020-10-01
Further Info :

Pubmed ID

26985180

DOI: Digital Object Identifier

PMC4793055

Related Literature

Article Analysis
・Side Effects of vemurafenib
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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