Paper Details

  1. Home
  2. Paper Details

Splenic irradiation before hematopoietic stem cell transplantation for chronic myeloid leukemia: long-term follow-up of a prospective randomized study.

Author: , ApperleyJane, ArceseWilliam, ArnoldRenate, BaldomeroHelen, BootsmanNatalia, BronDominique, CordonnierCatherine, ErnstPeter, FerrantAugustin, FrassoniFrancesco, GahrtonGösta, GratwohlAlois, IacobelliSimona, KolbHans Jochem, KrögerNicolaus, LinkHartmut, NiederwieserDietger, OlavarriaEduardo, RichardCarlos, RuutuTapani, SchattenbergAnton, SchmitzNorbert, Torres-GomezAntonio, ZwaanFerry, van BiezenAnja

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study re-analyzes a randomized trial on the role of splenic irradiation as an adjunct to hematopoietic stem cell transplantation (HSCT) for chronic myeloid leukemia (CML), finding that splenic irradiation does not improve survival outcomes.
Paper Details　
Original Abstract of the Article :
In the context of discussions on the reproducibility of clinical studies, we reanalyzed a prospective randomized study on the role of splenic irradiation as adjunct to the conditioning for hematopoietic stem cell transplantation (HSCT) for chronic myeloid leukemia (CML). Between 1986 and 1989, a tot...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1007/s00277-016-2638-6

データ提供：米国国立医学図書館（NLM）

Splenic Irradiation: A Controversial Adjunct to Hematopoietic Stem Cell Transplantation

The field of [hematology] is constantly seeking to optimize treatment strategies for [chronic myeloid leukemia (CML)]. This research re-analyzes the results of a [prospective randomized study] on the role of [splenic irradiation] as an [adjunct] to [hematopoietic stem cell transplantation (HSCT)] for [CML]. The authors explore the long-term impact of [splenic irradiation] on [overall survival], [relapse incidence], and [non-relapse mortality] in patients with [CML].

No Clear Benefit Found for Splenic Irradiation

The long-term follow-up data confirmed the [initial findings] of this study, showing [no significant differences] in [overall survival], [relapse incidence], [non-relapse mortality], or the risk of [late secondary malignancies] between patients who received [splenic irradiation] and those who did not. These results suggest that [splenic irradiation] may not be necessary as a [routine adjunct] to [HSCT] for [CML].

Navigating the Complex Landscape of CML Treatment

The treatment of [CML] is a complex journey, with a variety of options and considerations. This research highlights the importance of carefully evaluating the [potential benefits] and [risks] of each treatment approach. Just as a camel navigates a complex desert landscape, we must carefully weigh the evidence to ensure that treatment decisions are based on the most current scientific understanding and the patient's individual needs.

Dr. Camel's Conclusion

This re-analysis provides valuable long-term data on the role of splenic irradiation in CML treatment. It suggests that this procedure may not offer significant benefits and should be considered carefully in the context of other treatment options. Just like a camel adapting to the ever-changing desert, we must continually evaluate and refine our treatment strategies to ensure the best outcomes for patients with CML.

Date :
  1. Date Completed 2017-01-27
  2. Date Revised 2017-01-27
Further Info :

Pubmed ID

26994010

DOI: Digital Object Identifier

10.1007/s00277-016-2638-6

Related Literature

Article Analysis
・Effective treatment of chronic myeloid leukemia
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.