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Triethylenetetramine modulates polyamine and energy metabolism and inhibits cancer cell proliferation.

Author: AlhonenLeena, HyvönenMervi T, KeinänenTuomo A, KhomutovAlex R, KhomutovMaxim, PasanenMarkku, PeräniemiSirpa, UcalSebahat, VepsäläinenJouko, WeisellJanne

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that triethylenetetramine (TETA) inhibited polyamine metabolism in prostate, breast, and choriocarcinoma cells. TETA induced antizyme, down-regulated ornithine decarboxylase, and inhibited polyamine uptake.
Paper Details　
Original Abstract of the Article :
Polyamine metabolism is an attractive anticancer drug target, since polyamines are absolutely required for cellular proliferation, and increased levels of polyamines and their biosynthetic enzyme ornithine decarboxylase (ODC) are associated with cancer. Triethylenetetramine (TETA) is a charge-defici...See full text at original site
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引用元：
https://doi.org/10.1042/BCJ20160134

データ提供：米国国立医学図書館（NLM）

Triethylenetetramine: A Multi-Target Approach to Cancer Treatment

Polyamines are essential for cell growth and are often overproduced in cancer cells. This study investigates the anticancer potential of triethylenetetramine (TETA), a compound that inhibits polyamine metabolism and has been shown to have antitumor activity.

TETA: A Multi-Target Approach to Cancer Treatment

This study found that TETA effectively suppressed polyamine metabolism in cancer cells, leading to growth inhibition. TETA also inhibited the uptake of spermidine (Spd), a crucial polyamine, and prevented the increase in Spd uptake induced by α-difluoromethylornithine (DFMO), a known inhibitor of polyamine biosynthesis. Additionally, TETA suppressed the formation of hypusinated eukaryotic translation initiation factor 5A (eIF5A), a process essential for cell growth.

Navigating the Desert of Cancer Treatment: A Multifaceted Approach

This research highlights the promise of TETA as a multi-target anticancer drug. It's like finding a versatile camel in the desert of cancer treatment – one that can traverse multiple pathways to achieve a successful outcome. By targeting multiple pathways involved in cancer cell growth and survival, TETA offers a promising strategy for combating cancer.

Dr.Camel's Conclusion

TETA's ability to target multiple pathways involved in cancer cell growth makes it a promising candidate for anticancer therapy. It's like finding a new oasis in the desert of cancer treatment – one that offers a sustainable and multifaceted approach to combat this challenging disease.

Date :
  1. Date Completed 2017-05-15
  2. Date Revised 2017-12-16
Further Info :

Pubmed ID

27001865

DOI: Digital Object Identifier

10.1042/BCJ20160134

Related Literature

Article Analysis
・Effects of eflornithine
SNS
PICO Info
in preparation
Languages

English

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