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Toxicogenomic Effects in Rat Blood Leukocytes and Chemoprophylaxis of Radiation-Induced Carcinogenesis.

Author: AleksandrovV A, BespalovV G, IvanovS D, Kovan'koE G, SemenovA L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study found that Eleutherococcus extract significantly reduced genotoxicity in female rats exposed to ionizing γ-radiation. The extract's protective effects were observed in the endocrine and reproductive organs, leading to a decreased number and multiplicity of tumors.
Paper Details　
Original Abstract of the Article :
Toxicogenomic parameters were studied in the blood of female rats after exposure to ionizing γ-radiation in a dose of 4 Gy and chemoprophylaxis with α-difluoromethylornithine, eleutherococcus or leuzea extracts, which were used in animals with morphological manifestations of tumor growth under condi...See full text at original site
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引用元：
https://doi.org/10.1007/s10517-016-3255-z

データ提供：米国国立医学図書館（NLM）

Toxicogenomic Effects and Chemoprophylaxis in Radiation-Induced Carcinogenesis

Ionizing radiation can have detrimental effects on cells, potentially leading to cancer development. This study investigated the toxicogenomic effects of ionizing radiation in female rats and explored the potential chemoprotective effects of α-difluoromethylornithine, eleutherococcus, and leuzea extracts. The study used a variety of methods, including life-time evaluation of toxicogenomic effects and analysis of blood leukocytes, to assess the impact of radiation and potential chemoprotective agents.

Potential for Chemoprotection in Radiation-Induced Cancer

The study found that eleutherococcus extract showed potential chemoprotective effects against radiation-induced carcinogenesis in female rats. This finding suggests that eleutherococcus extract may have potential as a chemoprotective agent, mitigating the long-term risks associated with radiation exposure. Further research is needed to validate these findings and explore the mechanisms underlying the observed effects.

Navigating the Desert of Radiation Risk

This research provides valuable insights into the toxicogenomic effects of radiation and the potential for chemoprotection. It's like navigating a desert, where understanding the challenges of radiation exposure and exploring potential solutions is crucial for protecting human health.

Dr.Camel's Conclusion

This study explores the potential of eleutherococcus extract as a chemoprotective agent against radiation-induced carcinogenesis. It's like finding a hidden oasis in the vast desert of radiation risk, offering a glimmer of hope for mitigating the long-term consequences of radiation exposure.

Date :
  1. Date Completed 2017-01-09
  2. Date Revised 2017-01-10
Further Info :

Pubmed ID

27021083

DOI: Digital Object Identifier

10.1007/s10517-016-3255-z

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Languages

English

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