Paper Details

  1. Home
  2. Paper Details

Effects of adrenaline on circulatory dynamics and cardiac function in rats administered chlorpromazine.

Author: SakaiArisa, SunadaKatsuhisa

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigates the circulatory dynamics and cardiac function changes during concomitant use of chlorpromazine (CPZ) and adrenaline (AD) in rats. The study found that AD administration temporarily decreased blood pressure, but it was recovered by increased afterload and myocardial contractile force.
Paper Details　
Original Abstract of the Article :
We aimed to elucidate changes in circulatory dynamics and cardiac function during concomitant use of chlorpromazine (CPZ) and adrenaline (AD). An arterial line and left intraventricular pressure-volume measurement catheter were inserted in rats. CPZ 10 mg/kg was administered to the left great a...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1007/s10266-016-0241-x

データ提供：米国国立医学図書館（NLM）

Adrenaline and Chlorpromazine: A Complex Interaction in the Heart

In the field of [pharmacology and cardiovascular health], understanding how medications interact with each other and with the body's systems is crucial for ensuring safe and effective treatments. This study investigates the impact of adrenaline on circulatory dynamics and cardiac function in rats administered chlorpromazine, a commonly used antipsychotic medication, exploring the potential for drug-drug interactions within the cardiovascular system.

Adrenaline and Chlorpromazine: A Complex Interaction in the Heart

The study found that while adrenaline administration led to expected increases in heart rate and blood pressure in control rats, this response was altered in rats pre-treated with chlorpromazine. The researchers observed a transient decrease in blood pressure followed by a recovery, suggesting that co-administration of these medications might result in a complex interaction within the cardiovascular system. The study highlights the need for careful monitoring and consideration of potential interactions when administering adrenaline to patients taking chlorpromazine, particularly in situations like dental procedures where local anesthetics containing adrenaline are commonly used.

Adrenaline and Chlorpromazine: A Complex Interaction in the Heart

This study underscores the importance of understanding drug interactions and the potential implications for patient safety. It serves as a reminder that seemingly unrelated medications can interact in complex ways, potentially affecting cardiovascular function.

Dr. Camel's Conclusion

This research reminds me of the unpredictable nature of the desert, where a seemingly harmless oasis can sometimes hide hidden dangers. Just as a desert traveler must be aware of the potential for mirages, healthcare professionals must be vigilant about potential drug interactions, ensuring patient safety in the complex landscape of medication use.

Date :
  1. Date Completed 2018-02-08
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

27040284

DOI: Digital Object Identifier

10.1007/s10266-016-0241-x

Related Literature

Article Analysis
・Effects of chlorpromazine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.