Neratinib Plus Paclitaxel vs Trastuzumab Plus Paclitaxel in Previously Untreated Metastatic ERBB2-Positive Breast Cancer: The NEfERT-T Randomized Clinical Trial.

Author: AwadaAhmad, BachelotThomas, BadweRajendra A, BondarenkoIgor, BoseRon, BryceRichard, CareyLisa A, ColomerRamon, DemetriouGeorgia, DeoSuryanarayan, GoswamiChanchal, InoueKenichi, KimSung-Bae, LeeSoo-Chin, MehtaAjay O, WongAlvin, XuFeng, YaoBin

Paper Details 
Original Abstract of the Article :
IMPORTANCE: Efficacious ERBB2 (formerly HER2 or HER2/neu)-directed treatments, in addition to trastuzumab and lapatinib, are needed. OBJECTIVE: To determine whether neratinib, an irreversible pan-ERBB tyrosine kinase inhibitor, plus paclitaxel improves progression-free survival compared with trastu...See full text at original site
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引用元:
https://doi.org/10.1001/jamaoncol.2016.0237

データ提供:米国国立医学図書館(NLM)

Neratinib: A New Challenger in the Treatment of ERBB2-Positive Breast Cancer

This study investigates the efficacy of neratinib, a pan-ERBB tyrosine kinase inhibitor, in combination with paclitaxel for treating patients with previously untreated metastatic ERBB2-positive breast cancer. The research compares neratinib with trastuzumab, another established therapy for this type of cancer, seeking to determine if neratinib offers any significant advantages. The study found that neratinib and trastuzumab had comparable efficacy in terms of progression-free survival. However, neratinib was associated with a lower incidence of central nervous system metastases, suggesting a potential benefit in preventing brain metastases. This research provides valuable insights into the potential of neratinib as a new therapeutic option for treating ERBB2-positive breast cancer.

Neratinib: A Potential Game Changer for ERBB2-Positive Breast Cancer?

This study delves into the ever-evolving landscape of breast cancer treatment, comparing neratinib with trastuzumab, two powerful weapons in the fight against this disease. While the study found that neratinib and trastuzumab had similar overall efficacy, it revealed a potential advantage for neratinib in preventing brain metastases, a critical concern for patients with metastatic breast cancer. These findings encourage further research to confirm these observations and explore the full potential of neratinib in treating this challenging disease.

A New Path for ERBB2-Positive Breast Cancer Treatment: Exploring Neratinib's Potential

This study, like a caravan venturing into uncharted territory, explores the potential of neratinib as a new therapeutic option for treating ERBB2-positive breast cancer. It’s a reminder that the fight against cancer is an ongoing journey, with new discoveries and advancements constantly emerging. The study's findings encourage further research to investigate the potential benefits of neratinib, particularly in preventing brain metastases, and its place in the broader treatment landscape for ERBB2-positive breast cancer.

Dr.Camel's Conclusion

This study sheds light on the potential of neratinib as a new weapon in the fight against ERBB2-positive breast cancer. It’s a reminder that the quest for better treatments is ongoing, with new discoveries emerging that can potentially improve patient outcomes. Like a camel adapting to a changing desert landscape, we must continue to explore new avenues for treatment and find innovative solutions to combat this challenging disease.

Date :
  1. Date Completed 2017-02-17
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

27078022

DOI: Digital Object Identifier

10.1001/jamaoncol.2016.0237

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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