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Cinacalcet versus standard treatment for chronic kidney disease: a systematic review and meta-analysis.

Author: AgarwalArnav, BusseJason W, GuyattGordon H, LopesLuciane Cruz, MustafaReem A, SekerciogluM Fatih, SekerciogluNigar, ShaikhShaun, ThabaneLehana

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Chronic kidney disease-mineral and bone disorders (CKD-MBD) are associated with poor health outcomes. Standard management for CKD-MBD includes a phosphate restricted diet, vitamin D, and phosphate binders. Persistently elevated parathyroid hormone levels may necessitate the addition of cinacalcet hydrochloride, which sensitizes calcium receptors in the parathyroid gland.
Paper Details　
Original Abstract of the Article :
Chronic kidney disease-mineral and bone disorders (CKD-MBD) have been associated with poor health outcomes, including diminished quality and length of life. Standard management for CKD-MBD includes phosphate restricted diet, vitamin D and phosphate binders. Persistently elevated parathyroid hormone ...See full text at original site
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引用元：
https://doi.org/10.3109/0886022X.2016.1172468

データ提供：米国国立医学図書館（NLM）

Cinacalcet: A Potential Solution for Uncontrolled Parathyroid Hormone Levels in CKD?

The field of [chronic kidney disease (CKD)] treatment is continually searching for ways to address the complications of [CKD-mineral and bone disorders (CKD-MBD)]. This systematic review and meta-analysis examine the role of [cinacalcet hydrochloride (cinacalcet)] in managing [CKD-MBD]. The review focuses on the [efficacy of cinacalcet] as an [add-on therapy] to [standard CKD-MBD management], which includes [phosphate restricted diet, vitamin D, and phosphate binders]. The authors analyze the [current evidence] to evaluate the potential benefits of [cinacalcet] in controlling [persistently elevated parathyroid hormone levels] in [patients with CKD].

A Potential Tool for CKD Management

This systematic review and meta-analysis offer valuable insights into the potential role of [cinacalcet] in managing [CKD-MBD]. The findings, like a well-traveled desert route, indicate that [cinacalcet] might be a helpful tool for addressing [uncontrolled parathyroid hormone levels] in [patients with CKD]. The research underscores the importance of [comprehensive management approaches] for [CKD-MBD], incorporating [cinacalcet] as a potential therapeutic option.

A New Path for CKD-MBD Management

This review highlights the ongoing pursuit of effective treatments for [CKD-MBD]. Just as a camel navigates the desert landscape in search of sustenance, healthcare professionals are constantly searching for new strategies to improve the management of [CKD-MBD]. This research suggests that [cinacalcet] could be a valuable addition to the therapeutic arsenal for managing this complex condition.

Dr. Camel's Conclusion

This systematic review and meta-analysis offer a promising glimpse into the future of [CKD-MBD] management. Cinacalcet emerges as a potential therapeutic option for addressing [uncontrolled parathyroid hormone levels] in [patients with CKD]. Like a camel adapting to the harsh desert environment, we must continually strive for innovative treatments to improve the health and quality of life for those living with CKD.

Date :
  1. Date Completed 2017-04-10
  2. Date Revised 2022-04-10
Further Info :

Pubmed ID

27137817

DOI: Digital Object Identifier

10.3109/0886022X.2016.1172468

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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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