Safety and efficacy of additional levofloxacin in tuberculous meningitis: A randomized controlled pilot study.

Author: BetaiS, BhoiS K, KalitaJ, MisraU K

Paper Details 
Original Abstract of the Article :
BACKGROUND: Levofloxacin is an effective bactericidal category III antitubercular drug. There is paucity of studies comparing the role of additional levofloxacin to standard antitubercular regimen in the patients with tuberculous meningitis (TBM). AIMS: To compare the safety and efficacy of adding ...See full text at original site
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引用元:
https://doi.org/10.1016/j.tube.2016.01.004

データ提供:米国国立医学図書館(NLM)

Levofloxacin: A Desert Oasis for Tuberculous Meningitis?

Tuberculous meningitis (TBM) is like a fierce desert sandstorm, threatening the brain and central nervous system. Researchers are exploring the potential of levofloxacin, a potent bactericidal drug, to combat this formidable foe. They conducted a pilot study, comparing the safety and efficacy of adding levofloxacin to the standard antitubercular regimen (RHZE).

The study found that while levofloxacin might offer some benefits, it comes with a potential side effect: an increased risk of seizures. It's like a mirage in the desert, promising relief but carrying a hidden danger. The researchers observed no significant survival benefit in the levofloxacin group compared to the standard regimen, highlighting the importance of carefully weighing the potential risks and benefits.

Levofloxacin: A Balancing Act in the Desert

The results of this study suggest that levofloxacin's role in TBM treatment requires further exploration. It's essential to find the right balance, ensuring that the potential benefits outweigh the risks.

Navigating the Desert of TBM Treatment

TBM treatment requires a careful and strategic approach. This study reminds us that while new therapies might hold promise, thorough research is needed to understand their true value and ensure patient safety.

Dr.Camel's Conclusion

This study provides valuable insights into the potential role of levofloxacin in TBM treatment. It highlights the need for continued research to optimize treatment strategies and minimize the risk of adverse effects. Like a desert traveler, we must carefully navigate the terrain of TBM, seeking the best path to recovery.

Date :
  1. Date Completed 2017-11-13
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

27156611

DOI: Digital Object Identifier

10.1016/j.tube.2016.01.004

Related Literature

SNS
PICO Info
in preparation
Languages

English

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