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Relative Bioavailability of a Single Dose of Belimumab Administered Subcutaneously by Prefilled Syringe or Autoinjector in Healthy Subjects.

Author: BartonMatthew E, FireJoseph, FoxNorma Lynn, GilbertJane, GordonDavid, GroarkJames, MurtaughThomas, RothDavid, StruemperHerbert

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Both a single-use autoinjector and a prefilled syringe are suitable for subcutaneous self-administration of belimumab, a treatment for systemic lupus erythematosus.
Paper Details　
Original Abstract of the Article :
Intravenous belimumab is approved for the treatment of systemic lupus erythematosus; subcutaneous self-administration would enable greater patient access. This study assessed relative bioavailability, tolerability, and safety of 1 subcutaneous dose of self-administered belimumab by healthy subjects ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063175/

データ提供：米国国立医学図書館（NLM）

Navigating the Terrain of Belimumab Delivery

Belimumab, a medication used to treat systemic lupus erythematosus (SLE), has traditionally been administered intravenously. This study investigates the feasibility of subcutaneous self-administration of belimumab, exploring the relative bioavailability and safety of using a prefilled syringe or autoinjector. The researchers conducted a study in healthy subjects, comparing the pharmacokinetic profiles of belimumab administered subcutaneously using both devices. Their findings suggest that both the prefilled syringe and autoinjector offer comparable bioavailability, with a trend toward higher concentrations for thigh injections compared to abdominal injections.

Finding a More Convenient Oasis

This study provides valuable insights into the feasibility of subcutaneous self-administration of belimumab, a medication used for treating SLE. The findings suggest that both the prefilled syringe and autoinjector offer comparable bioavailability, paving the way for a more convenient and accessible treatment option for patients. This could be a game-changer for those seeking relief from SLE, providing a greater sense of control over their treatment regimen.

Empowering Patients with Self-Administration

As Dr. Camel, I'm always excited about advancements that empower patients to take a more active role in their healthcare. The potential for subcutaneous self-administration of belimumab, using either a prefilled syringe or autoinjector, offers a more convenient and accessible treatment option for patients with SLE. It's like finding a new path through the desert, leading to greater independence and control over their treatment journey.

Dr.Camel's Conclusion

This study explores the feasibility of subcutaneous self-administration of belimumab, using a prefilled syringe or autoinjector. The promising results suggest that both devices offer comparable bioavailability, paving the way for a more convenient and accessible treatment option for patients with SLE.

Date :
  1. Date Completed 2018-01-16
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

27163500

DOI: Digital Object Identifier

PMC5063175

Related Literature

Article Analysis
・Effects of belimumab injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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