Effects of ospemifene, a novel selective estrogen-receptor modulator, on human breast tissue ex vivo.

Author: EigelieneNatalija, ErkkolaRisto, HellmerChristina, HärkönenPirkko, KangasLauri, KaukoTommi

Paper Details 
Original Abstract of the Article :
Ospemifene (Osp) is a novel selective estrogen-receptor modulator (SERM) accepted for the treatment of dyspareunia, a symptom of postmenopausal vulvovaginal atrophy. We aimed to analyze the effects of Osp on human breast tissue (HBT), in comparison with the clinically established SERMs raloxifene (R...See full text at original site
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引用元:
https://doi.org/10.1097/GME.0000000000000624

データ提供:米国国立医学図書館(NLM)

Ospemifene: A New Oasis in the Desert of Vulvovaginal Atrophy

The [challenges of menopause] are well documented, with [vulvovaginal atrophy (VVA)] being a common and often distressing symptom. This study investigates the effects of [ospemifene (Osp)], a novel [selective estrogen-receptor modulator (SERM)], on [human breast tissue (HBT)] in comparison to other established SERMs, [raloxifene (Ral) and tamoxifen (Tam)].

The researchers used [ex vivo explant cultures] to study the effects of Osp on HBT. They found that Osp, similar to Ral and Tam, had minimal effects on breast tissue growth and differentiation. This finding is important because it suggests that Osp may be a safe and effective treatment option for VVA without significantly impacting breast tissue.

Ospemifene: A Potential Solution for VVA with Minimal Breast Tissue Effects

The study's findings suggest that Osp could be a valuable addition to the treatment options for VVA. Its minimal effects on breast tissue could make it a preferred choice for women who are concerned about the potential risks of breast tissue changes associated with other SERMs. This is like finding a hidden oasis in the desert of VVA treatment, offering a potentially safer and more effective solution.

Navigating the Desert of Menopausal Symptoms: A Focus on Personalized Care

This study highlights the importance of personalized care in managing the diverse symptoms of menopause. By carefully evaluating the potential benefits and risks of different treatment options, healthcare professionals can help women navigate the challenges of menopause and achieve optimal well-being.

Dr.Camel's Conclusion

This study is like a compass guiding us through the desert of menopausal symptoms. It suggests that Osp could be a safe and effective treatment option for VVA, offering a potential oasis for women seeking relief from this common and often distressing condition. It's a testament to the ongoing quest for better treatments for women navigating the challenges of menopause.

Date :
  1. Date Completed 2018-02-13
  2. Date Revised 2021-08-16
Further Info :

Pubmed ID

27163517

DOI: Digital Object Identifier

10.1097/GME.0000000000000624

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Languages

English

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