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Type I collagen and its daughter peptides for targeting mucosal healing in ulcerative colitis: A new treatment strategy.

Author: GopinathArun, HairulIslamVillianur Ibrahim, JabarisSugin Lal, MadhanBalaraman, PerumalRamesh Kannan, RamadassSatiesh Kumar

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Type I collagen and collagen hydrolysate have shown promise as healing matrices for internal mucosal ulceration in ulcerative colitis. Both treatments significantly reduced rectal bleeding, down-regulated pro-inflammatory cytokines, and facilitated faster regeneration of damaged mucosa compared to mesalamine and untreated controls.
Paper Details　
Original Abstract of the Article :
Ulcerative colitis, particularly the chronic persistent form is characterized by the presence of active inflammation and extensive areas of ulceration in the colonic mucosa. The existing treatment protocol aims at only reducing intestinal inflammation, rather than targeting mucosal ulceration. In th...See full text at original site
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引用元：
https://doi.org/10.1016/j.ejps.2016.05.015

データ提供：米国国立医学図書館（NLM）

Collagen and its Peptides for Mucosal Healing in Ulcerative Colitis

Ulcerative colitis, like a scorching desert wind, can be harsh on the digestive system. This study explores the potential of collagen and its peptides as a healing oasis for ulcerative colitis. The researchers discovered that collagen and collagen hydrolysate could effectively reduce rectal bleeding and inflammation, promoting mucosal healing in a mouse model. This offers a new treatment strategy for ulcerative colitis, potentially providing a more effective and targeted approach to healing.

Collagen and Collagen Hydrolysate: A Potential Oasis for Ulcerative Colitis

The study demonstrated that collagen and its peptides, collagen hydrolysate, have significant potential for treating ulcerative colitis. They reduced rectal bleeding and inflammation, indicating their ability to promote healing. These findings could lead to more effective and targeted treatments for ulcerative colitis, potentially improving the lives of millions suffering from this debilitating condition.

Navigating the Desert of Ulcerative Colitis

Collagen and its peptides offer a potential oasis for individuals navigating the desert of ulcerative colitis. These findings highlight the importance of exploring novel therapies to address the specific needs of this condition. While further research is needed, this study provides a promising starting point for developing new and effective treatment options for ulcerative colitis.

Dr. Camel's Conclusion

The researchers have discovered a potential oasis in the desert of ulcerative colitis! Collagen and its peptides seem to hold promise for promoting healing. While this study is promising, we need more research to confirm its effectiveness and safety. It's an exciting new direction that could lead to better treatments for ulcerative colitis.

Date :
  1. Date Completed 2017-04-17
  2. Date Revised 2017-04-17
Further Info :

Pubmed ID

27185300

DOI: Digital Object Identifier

10.1016/j.ejps.2016.05.015

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・Effects of mesalamine rectal
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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