Paper Details

  1. Home
  2. Paper Details

Therapeutic surfactant-stripped frozen micelles.

Author: AlexandridisPaschalis, ChitgupiUpendra, FederizonJasmin, GengJumin, LovellJonathan F, RzayevJavid, SongWentao, SukumaranDinesh K, UnsalHande, ZhangYumiao

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Validation StudyResearch to assess the validity and reliability of new measurement methods or diagnostic tests.

Overview

A new method for delivering hydrophobic drugs involves stripping away surfactants from Pluronic block copolymers, leaving behind concentrated drug micelles with minimal solubilizing excipient. This method was validated for 9 bioactive molecules and achieved sizes between 45 and 160 nm, with drug to solubilizer molar ratios 2-3 orders of magnitude higher than current formulations.
Paper Details　
Original Abstract of the Article :
Injectable hydrophobic drugs are typically dissolved in surfactants and non-aqueous solvents which can induce negative side-effects. Alternatives like 'top-down' fine milling of excipient-free injectable drug suspensions are not yet clinically viable and 'bottom-up' self-assembled delivery systems u...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874033/

データ提供：米国国立医学図書館（NLM）

Surfactant-Stripped Frozen Micelles: A New Frontier in Drug Delivery

Injectable hydrophobic drugs often require the use of surfactants, which can lead to adverse side effects, like a desert sandstorm that can irritate delicate skin. This study explores a novel approach for delivering hydrophobic drugs, using surfactant-stripped frozen micelles, to minimize these side effects. The researchers embarked on a journey to create a safer and more effective delivery system for these drugs, seeking to find a smooth path through the desert of drug delivery.

The study demonstrates the feasibility of using surfactant-stripped frozen micelles for delivering a variety of hydrophobic drugs. The researchers achieved drug-to-solubilizer molar ratios 2-3 orders of magnitude higher than current formulations, potentially improving drug efficacy and reducing side effects. This innovation could lead to a new era of safer and more effective drug delivery, potentially transforming the landscape of pharmaceutical development.

A Safer and More Effective Delivery System

This study highlights the potential of surfactant-stripped frozen micelles as a safer and more effective delivery system for hydrophobic drugs. The researchers demonstrate the feasibility of this approach, offering a promising avenue for developing novel drug delivery systems with fewer side effects. This research could lead to a new era of more effective and safer drug delivery, potentially transforming the landscape of pharmaceutical development.

A Smooth Path Through the Desert

This research explores the potential of surfactant-stripped frozen micelles as a new approach for delivering hydrophobic drugs, offering a smooth path through the desert of drug delivery. The researchers demonstrate the feasibility of this approach, offering a promising avenue for developing novel drug delivery systems with fewer side effects.

Dr.Camel's Conclusion

The desert of drug delivery can be a challenging terrain, but researchers are constantly seeking to find new and safer ways to deliver medications. This study explores the potential of surfactant-stripped frozen micelles, offering a promising new approach for delivering hydrophobic drugs with fewer side effects. This innovation could lead to a new era of more effective and safer drug delivery, potentially transforming the landscape of pharmaceutical development.

Date :
  1. Date Completed 2018-09-20
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

27193558

DOI: Digital Object Identifier

PMC4874033

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.