Paper Details

  1. Home
  2. Paper Details

Redox nanoparticle increases the chemotherapeutic efficiency of pioglitazone and suppresses its toxic side effects.

Author: NagasakiYukio, SakharkarMeena Kishore, ThangavelSindhu, YoshitomiToru

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

RNP(N), a nitroxide-radical containing nanoparticle, was used to encapsulate pioglitazone, enhancing its solubility, cellular uptake, and antitumor efficacy while reducing liver toxicity.
Paper Details　
Original Abstract of the Article :
Pioglitazone is a widely used anti-diabetic drug that induces cytotoxicity in cancer cells; however, its clinical use is questioned due to its associated liver toxicity caused by increased oxidative stress. We therefore employed nitroxide-radical containing nanoparticle, termed redox nanoparticle (R...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.biomaterials.2016.05.001

データ提供：米国国立医学図書館（NLM）

Redox Nanoparticle: A New Approach to Enhance Chemotherapy

Pioglitazone, an anti-diabetic drug, shows potential for cancer treatment by inducing cytotoxicity in cancer cells. However, its clinical use is limited due to liver toxicity caused by oxidative stress. This study investigates the use of redox nanoparticles (RNP(N)), which scavenge reactive oxygen species (ROS), as drug carriers for pioglitazone. The researchers examine the effects of RNP(N) encapsulation on pioglitazone's solubility, cellular uptake, and therapeutic efficacy, both in vitro and in vivo.

Redox Nanoparticle's Advantages: A Double-Edged Sword

The study demonstrates that RNP(N) encapsulation enhances pioglitazone's solubility and cellular uptake, leading to improved anticancer effects. Importantly, RNP(N) effectively mitigates the liver toxicity associated with pioglitazone.

Redox Nanoparticle's Promise: Safer Chemotherapy

This research showcases the potential of RNP(N) as a promising strategy to enhance the therapeutic efficacy of pioglitazone while reducing its toxic side effects. This approach could significantly advance the use of pioglitazone for cancer treatment.

Dr. Camel's Conclusion

Think of a desert oasis, a place of life and healing. RNP(N) acts like a protective oasis, shielding pioglitazone from the harmful effects of oxidative stress, allowing it to reach its target, the cancer cells, with minimal damage to surrounding tissues. This research shows the power of nanotechnology to improve drug delivery and reduce toxicity.

Date :
  1. Date Completed 2018-02-22
  2. Date Revised 2018-12-03
Further Info :

Pubmed ID

27235996

DOI: Digital Object Identifier

10.1016/j.biomaterials.2016.05.001

Related Literature

Article Analysis
・Side Effects of pioglitazone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.