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The radiosensitizing effects of Nelfinavir on pancreatic cancer with and without pancreatic stellate cells.

Author: Al-AssarOsama, BittnerMartin-Immanuel, BrunnerThomas B, LunardiSerena, McKennaW Gillies, StratfordMichael R

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study aimed to investigate the influence of pancreatic stellate cells (PSCs) on nelfinavir-mediated radiosensitization to pancreatic ductal adenocarcinoma (PDAC) preclinically.
Paper Details　
Original Abstract of the Article :
We have previously shown in a phase I trial that nelfinavir (NFV) is safe with chemoradiation in PDAC with good signs for efficacy. Reverse translationally, we aimed to test the influence of PSCs on nelfinavir mediated radiosensitization to PDAC preclinically, because PDAC is very rich in desmoplasi...See full text at original site
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引用元：
https://doi.org/10.1016/j.radonc.2016.03.024

データ提供：米国国立医学図書館（NLM）

Radiosensitizing Pancreatic Cancer: The Role of Nelfinavir

This study explores the potential of nelfinavir (NFV) as a radiosensitizer for pancreatic cancer (PDAC). NFV is a protease inhibitor commonly used to treat HIV infection. The study investigates the influence of pancreatic stellate cells (PSCs), which play a significant role in the resistance of PDAC to radiation therapy. The researchers examined the radiosensitizing effects of NFV on PDAC cells in the presence and absence of PSCs.

Nelfinavir Enhances Radiosensitivity in Pancreatic Cancer

The study found that NFV enhanced the radiosensitivity of PDAC cells, both with and without PSCs. The results suggest that NFV could potentially be used as a radiosensitizing agent in combination with radiation therapy for PDAC. The authors hypothesize that NFV's radiosensitizing effects might be related to its ability to inhibit the activity of PSCs, thereby reducing their resistance to radiation.

A New Treatment Strategy for Pancreatic Cancer: Combating Resistance

This research offers a potential new treatment strategy for PDAC by combining radiation therapy with NFV. This combination could overcome the resistance of PDAC to radiation and improve treatment outcomes. Think of NFV as a special kind of desert plant that grows in harsh conditions and can help other plants survive. By combining NFV with radiation therapy, we can create a more favorable environment for fighting cancer.

Dr. Camel's Conclusion

This study demonstrates the potential of nelfinavir as a radiosensitizing agent for pancreatic cancer. This research offers a new treatment strategy that could improve patient outcomes by overcoming the resistance of pancreatic cancer to radiation therapy. Finding new treatment strategies for this challenging disease is like searching for a hidden oasis in a vast desert; it requires careful exploration and innovative approaches.
Date :
  1. Date Completed 2017-02-13
  2. Date Revised 2022-01-29
Further Info :

Pubmed ID

27247056

DOI: Digital Object Identifier

10.1016/j.radonc.2016.03.024

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in preparation
Languages

English

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