Paper Details

  1. Home
  2. Paper Details

Antileishmanial activity of antiretroviral drugs combined with miltefosine.

Author: CavadasCláudia, CostaSonya, MachadoMarisa, do Céu SousaMaria

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Efavirenz, a non-nucleoside reverse transcriptase inhibitor, showed antileishmanial activity against Leishmania infantum. The combination of efavirenz with miltefosine improved antileishmanial activity, suggesting it as a potential treatment option for Leishmaniasis and Leishmania/HIV co-infections.
Paper Details　
Original Abstract of the Article :
Co-infection of Leishmaniasis, a neglected tropical disease, with human immunodeficiency virus (HIV) has hindered treatment efficacy. In this study, we aim to evaluate the antileishmanial activity of two protease inhibitors (darunavir and atazanavir) and four reverse transcriptase inhibitors (tenofo...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1007/s00436-016-5153-8

データ提供：米国国立医学図書館（NLM）

A Combined Approach: Tackling Leishmaniasis and HIV Co-Infection

The battle against [leishmaniasis], a neglected tropical disease, is often complicated by the presence of [HIV co-infection]. This study investigates the potential of combining [antiretroviral drugs] with [miltefosine], a drug commonly used to treat leishmaniasis, to enhance treatment efficacy. The authors examined the antileishmanial activity of various antiretroviral drugs, both individually and in combination with miltefosine, against Leishmania infantum.

A New Frontier in Treatment: The Promise of Combined Therapy

This study reveals the potential of combined therapy, involving efavirenz and miltefosine, for treating leishmaniasis and Leishmania/HIV co-infections. The observed synergistic effect of these two drugs suggests a promising avenue for improving treatment outcomes in this challenging clinical setting. This research opens the door to new treatment strategies for these complex infections, potentially leading to improved patient outcomes and a better future for individuals affected by these diseases.

Hope for the Future: A Journey Towards Improved Treatment Options

This study offers a glimmer of hope for individuals battling leishmaniasis, particularly those with HIV co-infection. The potential of combined therapy using efavirenz and miltefosine provides a promising avenue for improving treatment outcomes and reducing the burden of these diseases. This research underscores the importance of ongoing research into new treatment strategies for neglected tropical diseases, particularly those that often affect vulnerable populations.

Dr. Camel's Conclusion

This study explores the exciting potential of combining antiretroviral drugs with miltefosine for treating leishmaniasis, particularly in the context of HIV co-infection. The research offers a ray of hope for individuals battling these complex infections, highlighting the importance of ongoing research and development of new treatment strategies for neglected tropical diseases.

Date :
  1. Date Completed 2017-06-28
  2. Date Revised 2020-12-09
Further Info :

Pubmed ID

27249967

DOI: Digital Object Identifier

10.1007/s00436-016-5153-8

Related Literature

Article Analysis
・Effects of delavirdine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.