Effects of bosentan on peripheral endothelial function in patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension.

Author: AdachiShiro, HirashikiAkihiro, KamimuraYoshihiro, KondoTakahisa, MuroharaToyoaki, NakanoYoshihisa, ShimokataShigetake, TakeshitaKyosuke

Paper Details 
Original Abstract of the Article :
Endothelin receptor antagonists (ERAs) have been shown to improve the prognosis of patients with pulmonary arterial hypertension (PAH). However, the effect of the oral dual ERA bosentan on peripheral endothelial dysfunction (PED), as assessed by flow-mediated vasodilation (FMD), in patients with pul...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869920/

データ提供:米国国立医学図書館(NLM)

Bosentan: A Journey to Improve Endothelial Function in Pulmonary Hypertension

Pulmonary arterial hypertension (PAH), a condition where the arteries in the lungs become narrowed and constricted, is like a sandstorm raging through the delicate airways. This study explores the impact of bosentan, a medication that blocks endothelin receptors, on peripheral endothelial function in patients with PAH or chronic thromboembolic pulmonary hypertension (CTEPH).

The study, conducted by researchers, found that bosentan improved peripheral endothelial function in patients with PAH, as measured by flow-mediated vasodilation (FMD), but not in patients with CTEPH. This research, like a desert explorer discovering a hidden oasis, reveals the potential of bosentan to improve blood vessel function in PAH, offering a glimmer of hope for improving outcomes in these patients.

Bosentan: A Potential Solution for Endothelial Dysfunction in PAH

The study's findings suggest that bosentan may be a valuable tool for improving endothelial function in patients with PAH, potentially mitigating the effects of this debilitating condition. This research, like a skilled desert guide navigating a challenging terrain, offers a promising avenue for managing PAH and improving the lives of patients affected by this condition.

Improving Outcomes in Pulmonary Hypertension: A Journey Toward Healthier Lungs

This study explores the potential of bosentan to improve endothelial function in patients with PAH, offering a glimmer of hope for a brighter future for those struggling with this condition. By understanding the mechanisms of PAH and the potential benefits of bosentan, researchers are paving the way for more effective treatments and a better quality of life for patients.

Dr.Camel's Conclusion

This study reveals the potential of bosentan to improve endothelial function in PAH, offering a beacon of hope for patients struggling with this debilitating condition. Like a desert traveler discovering a hidden spring, researchers are uncovering new pathways to managing PAH and improving the lives of patients affected by this disease. This research underscores the ongoing journey to find more effective treatments for PAH, offering a brighter future for those battling this challenging condition.

Date :
  1. Date Completed 2016-06-02
  2. Date Revised 2020-09-29
Further Info :

Pubmed ID

27252842

DOI: Digital Object Identifier

PMC4869920

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Languages

English

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