The effects of apremilast on the QTc interval in healthy male volunteers: a formal, thorough QT study.

Author: AssafMahmoud, LiuLiangang, LiuYong, PalmisanoMaria, ParkC Hyung, SavantIshani, WuAnfan, ZhouSimon

Paper Details 
Original Abstract of the Article :
OBJECTIVE: This study was conducted to evaluate the effect of apremilast and its major metabolites on the placebocorrected change-from-baseline QTc interval of an electrocardiogram (ECG). MATERIALS AND METHODS: Healthy male subjects received each of 4 treatments in a randomized, crossover manner. I...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949396/

データ提供:米国国立医学図書館(NLM)

Apremilast: A Safe Journey through the Desert of Cardiac Rhythm

In the vast desert of cardiovascular research, maintaining a steady heart rhythm is crucial. This study focuses on apremilast, a medication used to treat psoriasis, investigating its potential impact on the heart's electrical activity. Much like a camel carefully navigating treacherous dunes, researchers wanted to ensure apremilast wouldn't disrupt the heart's rhythm.

Apremilast and the Heart: A Safe Oasis

The study involved healthy male volunteers who received apremilast or a placebo, with their heart rhythm closely monitored. The results were reassuring, showing that apremilast did not prolong the QT interval, a measure of the heart's electrical activity. This finding suggests that apremilast is unlikely to cause dangerous heart rhythm disturbances, providing a safe oasis in the desert of cardiac rhythm.

Navigating the Desert with Confidence

This research provides valuable insights into the safety profile of apremilast, ensuring that patients with psoriasis can benefit from this medication without the worry of potentially dangerous heart rhythm disturbances. It's like finding a well-marked trail through a treacherous desert, allowing us to confidently navigate the path toward treatment.

Dr.Camel's Conclusion

This study provides a reassuring oasis in the desert of cardiovascular research, demonstrating the safety of apremilast for the heart. It underscores the importance of careful research and rigorous testing to ensure the safety and efficacy of medications, allowing us to confidently navigate the complexities of the desert of medicine.

Date :
  1. Date Completed 2017-01-27
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

27285466

DOI: Digital Object Identifier

PMC4949396

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Languages

English

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