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Effects of S-Nitroso-N-Acetyl-Penicillamine (SNAP) on Inflammation, Lung Tissue Apoptosis and iNOS Activity in a Rabbit Model of Acute Lung Injury.

Author: BalentovaS, CalkovskaA, KolomaznikM, KosutovaP, MikolkaP, MokraD

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study evaluated the effects of S-nitroso-N-acetyl-penicillamine (SNAP) on experimental acute lung injury (ALI) in rabbits. ALI was induced by repetitive lung lavage with saline. SNAP therapy reduced cell migration into the lungs and decreased pro-inflammatory and apoptotic markers.
Paper Details　
Original Abstract of the Article :
Acute lung injury is characterized by lung edema, surfactant dysfunction, and inflammation. The main goal of our study was to evaluate effects of S-nitroso-N-acetyl-penicillamine (SNAP) on migration of cells into the lung and their activation, inducible NO synthase (iNOS) activity, and apoptosis in ...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1007/5584_2016_34

データ提供：米国国立医学図書館（NLM）

S-Nitroso-N-Acetyl-Penicillamine (SNAP) in the Treatment of Acute Lung Injury

This study explores the potential therapeutic benefits of S-nitroso-N-acetyl-penicillamine (SNAP) in the context of acute lung injury (ALI). The study, using a rabbit model of ALI, investigated the effects of SNAP on inflammation, lung tissue apoptosis, and iNOS activity. The researchers meticulously analyzed various parameters, including cell migration, pro-inflammatory cytokine levels, and apoptotic markers. Their findings suggest that SNAP could play a significant role in mitigating the detrimental effects of ALI.

SNAP: A Potential Ally Against Acute Lung Injury

The study observed that SNAP therapy effectively reduced the influx of inflammatory cells into the lungs, lowered the production of pro-inflammatory substances, and decreased the expression of apoptotic markers. These results highlight the potential of SNAP in attenuating the inflammatory cascade and mitigating cell death in ALI, offering a promising avenue for therapeutic intervention.

Navigating the Turbulent Waters of Acute Lung Injury

This research underscores the critical need to explore novel therapeutic approaches for managing ALI. The study’s findings on SNAP provide a valuable insight into the potential for therapeutic strategies targeting inflammation and cell death, paving the way for future research and clinical applications.

Dr. Camel's Conclusion

This study offers a promising glimpse into the therapeutic landscape of acute lung injury. The findings suggest that SNAP could be a valuable tool in combating the inflammatory response and mitigating cell damage. It's like finding a hidden oasis of hope in the midst of a lung injury storm.
Date :
  1. Date Completed 2017-12-05
  2. Date Revised 2017-12-05
Further Info :

Pubmed ID

27334732

DOI: Digital Object Identifier

10.1007/5584_2016_34

Related Literature

Article Analysis
・Effects of penicillamine
SNS
PICO Info
in preparation
Languages

English

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