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Lorcaserin Administration Decreases Activation of Brain Centers in Response to Food Cues and These Emotion- and Salience-Related Changes Correlate With Weight Loss Effects: A 4-Week-Long Randomized, Placebo-Controlled, Double-Blind Clinical Trial.

Author: CampMichelle, FarrOlivia M, GavrieliAnna, KayeHarper, KilimHolly, KoniarisAnastasia, MantzorosChristos S, MathewHannah, MigdalAlexandra, SpyrouNikolaos, SrnkaAlexandra, UpadhyayJagriti, VamviniMaria

Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Lorcaserin, a serotonin 5-hydroxytryptamine 2c receptor agonist, is effective in treating obesity. This study found that lorcaserin decreases brain activation in response to food cues, particularly in areas related to attention and emotion. The study also found that baseline activation of the amygdala was associated with increased efficacy, suggesting that lorcaserin may be particularly beneficial for emotional eaters.
Paper Details　
Original Abstract of the Article :
Lorcaserin is a serotonin 5-hydroxytryptamine 2c receptor agonist effective in treating obesity. Studies in rodents have shown that lorcaserin acts in the brain to exert its weight-reducing effects, but this has not yet been studied in humans. We performed a randomized, placebo-controlled, double-bl...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033259/

データ提供：米国国立医学図書館（NLM）

Lorcaserin Administration Decreases Brain Activation in Response to Food Cues

This research investigates the effects of lorcaserin, a serotonin 5-hydroxytryptamine 2c receptor agonist used to treat obesity, on brain activity in response to food cues. The researchers conducted a randomized, placebo-controlled, double-blind trial involving 48 obese participants, using functional MRI to study the effects of lorcaserin on brain activity.

Lorcaserin's Impact on Brain Activity

The researchers found that lorcaserin decreased brain activation in response to highly palatable food cues in areas associated with attention, such as the parietal and visual cortices. These effects were observed both in the fasting and fed states. The researchers also found that lorcaserin attenuated decreases in emotion- and salience-related limbic activity, including the insula and amygdala.

Potential for Personalized Weight Management

This study suggests that lorcaserin may exert its weight-reducing effects by decreasing attention-related brain activations to food cues and emotional and limbic activity. It's like a camel caravan learning to avoid treacherous mirages – lorcaserin may help individuals focus on healthy choices and reduce cravings. The researchers emphasize the need for further research to explore the potential of lorcaserin as a personalized weight management tool.

Dr. Camel's Conclusion

This research explores the effects of lorcaserin on brain activity in response to food cues, suggesting its potential as a personalized weight management tool. It's like a camel caravan navigating a vast and challenging desert – a skilled guide knows how to identify and avoid treacherous mirages. The researchers advocate for further research to explore the potential of lorcaserin as a personalized weight management tool.

Date :
  1. Date Completed 2017-05-19
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

27385157

DOI: Digital Object Identifier

PMC5033259

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PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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