Hyperglycemia induced by pasireotide in patients with Cushing's disease or acromegaly.

Author: SilversteinJulie M

Paper Details 
Original Abstract of the Article :
Cushing's disease (CD) and acromegaly are characterized by excessive hormone secretion resulting in comorbidities such as impaired glucose metabolism, diabetes and hypertension. Pasireotide is a new-generation, multireceptor-targeted somatostatin receptor ligand approved for CD (subcutaneous [SC] in...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996868/

データ提供:米国国立医学図書館(NLM)

Pasireotide and Hyperglycemia: A Balancing Act in Cushing's Disease and Acromegaly

Endocrinology, the study of hormones, faces the challenge of managing conditions like Cushing's disease and acromegaly, which involve excessive hormone secretion. Pasireotide, a new drug, has emerged as a potential treatment for these conditions. However, this research highlights a significant side effect: hyperglycemia, an increase in blood sugar levels. The authors reviewed clinical trials involving pasireotide and discussed the differences in reported hyperglycemia rates and potential risk factors.

Pasireotide-Associated Hyperglycemia: A Common Occurrence

The review found that hyperglycemia-related adverse events were frequently observed in clinical trials of pasireotide. This finding suggests that hyperglycemia is a common side effect of pasireotide treatment. The authors emphasize the importance of monitoring blood sugar levels in patients receiving pasireotide and implementing appropriate management strategies to mitigate the risk of hyperglycemia.

Managing Hyperglycemia in Pasireotide Treatment

This research emphasizes the need for close monitoring of blood glucose levels in patients receiving pasireotide. Early detection and management of hyperglycemia are crucial for preventing long-term complications. Just as a desert oasis provides vital hydration, proper monitoring and management can help patients navigate the potential challenges of pasireotide treatment.

Dr.Camel's Conclusion

Pasireotide holds promise for treating Cushing's disease and acromegaly. However, like an oasis that can also be a source of mirages, pasireotide requires careful management to avoid the potential pitfalls of hyperglycemia. This research provides valuable information for doctors and patients to make informed decisions about treatment and management.

Date :
  1. Date Completed 2017-04-04
  2. Date Revised 2022-04-20
Further Info :

Pubmed ID

27405306

DOI: Digital Object Identifier

PMC4996868

Related Literature

SNS
PICO Info
in preparation
Languages

English

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