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Immunogenic Human Papillomavirus Pseudovirus-Mediated Suicide-Gene Therapy for Bladder Cancer.
Author: DerréLaurent, Domingos-PereiraSonia, GharbiDalila, HojeijRim, JichlinskiPatrice, Nardelli-HaefligerDenise, NkosiMarianne, SchillerJohn T
Original Abstract of the Article :
Bladder cancer is the second most common urological malignancy in the world. In 70% of cases it is initially diagnosed as non-muscle-invasive bladder cancer (NMIBC) and it is amenable to local treatments, with intravesical (IVES) Bacillus-Calmette-Guerin (BCG) immunotherapy being routinely used afte...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964499/
データ提供:米国国立医学図書館(NLM)
Human Papillomavirus Pseudovirus-Mediated Suicide-Gene Therapy: A Targeted Attack on Bladder Cancer
Bladder cancer is a challenging disease, and this study investigates a novel treatment strategy utilizing human papillomavirus non-replicative pseudovirions (PsV) for targeted suicide-gene therapy. The research explores the potential of PsV carrying the herpes-simplex virus thymidine kinase (PsV-TK) gene, combined with Ganciclovir (GCV), in inducing immunogenic cell death in bladder cancer cells. The study demonstrates the effectiveness of this approach in reducing tumor growth and increasing survival rates in a mouse model.
A New Weapon in the Fight Against Bladder Cancer: Targeted Therapy with PsV
This study showcases the potential of PsV-mediated suicide-gene therapy as a promising treatment strategy for bladder cancer. The findings suggest that this targeted approach could be a powerful tool in the fight against this disease. Think of it like a guided missile – precisely targeting the tumor cells and minimizing damage to surrounding healthy tissues.
Navigating the Bladder Cancer Desert: A Multifaceted Approach
This research highlights the importance of exploring new and innovative treatment approaches for bladder cancer. The PsV-mediated suicide-gene therapy offers a promising alternative to conventional treatments. Just like a desert traveler needs to be resourceful and adaptable, we need to embrace new technologies and strategies in combating this challenging disease.
Dr.Camel's Conclusion
This study offers a ray of hope for patients battling bladder cancer. The PsV-mediated suicide-gene therapy demonstrates the potential for targeted and effective treatments. It’s like finding a hidden oasis in a vast desert – a source of hope and renewal. This research encourages further exploration of this promising strategy to combat bladder cancer.
Date :
- Date Completed 2017-03-21
- Date Revised 2018-11-13
Further Info :
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