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Berbamine inhibited the growth of prostate cancer cells in vivo and in vitro via triggering intrinsic pathway of apoptosis.

Author: ChenJ, JinX B, LvJ J, SuZ H, WangL Y, WangM W, ZhangH Y, ZhaoY

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Berbamine (BBM) effectively inhibited prostate cancer (PCa) cell growth in vitro and in vivo by inducing apoptosis through the mitochondrial pathway. BBM activated caspase-3, leading to cell death.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Berbamine (BBM) has been reported with antitumor activities. BBM inhibited the growth of prostate cancer (PCa) cells and caused vacuolization of mitochondria in preliminary study. We hypothesized BBM could enhance apoptosis of PCa cells through mitochondrial pathway. METHODS: Growth of ...See full text at original site
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引用元：
https://doi.org/10.1038/pcan.2016.29

データ提供：米国国立医学図書館（NLM）

Berbamine: A Promising Agent for Prostate Cancer Treatment

This research ventures into the complex landscape of prostate cancer, exploring the potential of berbamine, a natural compound, as a treatment for this prevalent disease. Imagine a desert with hidden springs and oases that hold the key to overcoming a challenging obstacle. Similarly, prostate cancer presents a significant health challenge, requiring innovative approaches to treatment. This study, like an intrepid explorer seeking out a hidden oasis, investigates the anti-tumor effects of berbamine, examining its ability to induce apoptosis, or programmed cell death, in prostate cancer cells.

Berbamine: A Potential Weapon Against Prostate Cancer

This study suggests that berbamine may hold promise as a treatment for prostate cancer. It's like discovering a hidden spring in the desert, offering a potent weapon against this challenging disease. The study's findings demonstrate that berbamine effectively inhibits the growth of prostate cancer cells both in vitro and in vivo, showcasing its potential as a therapeutic agent.

Hope for Prostate Cancer Patients

This study offers a glimmer of hope for prostate cancer patients. It's like finding a new path through the desert of cancer treatment, potentially leading to more effective and less toxic therapies. However, it's crucial to remember that further research is needed to fully understand the efficacy and safety of berbamine in treating prostate cancer.

Dr.Camel's Conclusion

This study unveils a potential oasis in the desert of prostate cancer treatment, showcasing the promising effects of berbamine. It's like finding a hidden spring, offering a potent weapon against this challenging disease.

Date :
  1. Date Completed 2018-01-25
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

27431500

DOI: Digital Object Identifier

10.1038/pcan.2016.29

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