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Benzolamide improves oxygenation and reduces acute mountain sickness during a high-altitude trek and has fewer side effects than acetazolamide at sea level.
Author: CollierDavid J, FlowerRod J, HedgesAnne-Marie, MilledgeJames S, NathanJohn, SwensonErik R, WolffChris B
Original Abstract of the Article :
Acetazolamide is the standard carbonic anhydrase (CA) inhibitor used for acute mountain sickness (AMS), however some of its undesirable effects are related to intracellular penetrance into many tissues, including across the blood-brain barrier. Benzolamide is a much more hydrophilic inhibitor, which...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876137/
データ提供:米国国立医学図書館(NLM)
Benzolamide: A New Camel for Navigating the Altitude Sickness Desert
The journey to high altitudes can be a challenging one, especially for those who experience acute mountain sickness (AMS). It's like navigating a vast and unforgiving desert, where the thin air can take its toll on the body. This research focuses on benzolamide, a carbonic anhydrase inhibitor, and its potential to alleviate AMS symptoms. It's like discovering a new, more resilient species of camel that can thrive in the harshest desert environments, offering a better chance of survival in the face of altitude sickness.
The study investigated the effectiveness of benzolamide versus placebo in a group of individuals trekking to the Everest Base Camp. The authors found that benzolamide significantly improved arterial oxygenation and reduced AMS severity compared to placebo. They also found that benzolamide had fewer side effects than acetazolamide, the standard treatment for AMS. It's like finding a hidden oasis that provides relief from the harsh conditions of altitude sickness, without disrupting the overall balance of the body.
Benzolamide: A Promising Solution for Acute Mountain Sickness
The study's findings suggest that benzolamide may offer a promising solution for AMS, potentially providing a more comfortable and effective way to navigate high altitudes. It's like finding a new, more effective tool for navigating the desert of altitude sickness, offering a better chance of reaching your destination without succumbing to the harsh conditions.
Navigating the Desert of Altitude Sickness: A Journey of Preparation
While benzolamide shows promise, it's important to remember that it's just one piece of the puzzle in the complex landscape of altitude sickness management. It's like navigating a vast desert – one must utilize all the resources available and approach each challenge with a multifaceted strategy. Further research is needed to optimize the use of benzolamide and explore other potential interventions, ensuring that we're always navigating toward the best possible outcomes for those venturing to high altitudes.
Dr. Camel's Conclusion
This research offers a new camel for navigating the desert of altitude sickness. Benzolamide shows promise as a safe and effective treatment option, potentially improving the comfort and well-being of those venturing to high altitudes. It's a journey of discovery, as we continue to seek new and innovative ways to conquer the challenges of altitude sickness.
Date :
- Date Completed 2016-07-19
- Date Revised 2021-01-09
Further Info :
Related Literature
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