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Effects of pentoxifylline on inflammatory markers and blood pressure: a systematic review and meta-analysis of randomized controlled trials.

Author: , AhmedAli, AronowWilbert S, BanachMaciej, BrieDaniel, DincaMadalina, HowardGeorge, LipGregory Y H, MuntnerPaul, PensonPeter E, RyszJacek, SahebkarAmirhossein, SerbanMaria-Corina, UrsoniuSorin, WongNathan D, ZanchettiAlberto

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This systematic review and meta-analysis of 15 randomized controlled trials found that pentoxifylline did not alter blood pressure or plasma IL-6 concentration, but significantly reduced circulating TNF-α and CRP concentrations. The impact of pentoxifylline on TNF-α levels was associated with treatment duration, but independent of pentoxifylline dose.
Paper Details　
Original Abstract of the Article :
INTRODUCTION: Pentoxifylline is a xanthine derivative with potential cardiovascular benefits. AIM: To evaluate the impact of pentoxifylline on blood pressure (BP) and plasma TNF-α, C-reactive protein (CRP) and IL-6 through a systematic review and meta-analysis of randomized controlled trials. METH...See full text at original site
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引用元：
https://doi.org/10.1097/HJH.0000000000001086

データ提供：米国国立医学図書館（NLM）

Effects of Pentoxifylline on Inflammatory Markers and Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

This research delves into the vast desert of [pharmacology and cardiovascular medicine], specifically investigating the effects of [pentoxifylline] on [inflammatory markers and blood pressure]. Much like a camel seeking a source of water in a parched landscape, researchers embarked on a systematic review and meta-analysis of randomized controlled trials to understand the impact of pentoxifylline. The study found that pentoxifylline did not significantly alter [blood pressure], but it did lead to a [significant reduction in plasma concentrations of TNF-α and CRP]. This study provides valuable insights into the potential benefits of pentoxifylline as a [modulator of inflammation], potentially offering a new avenue for managing inflammatory conditions.

Pentoxifylline: A Potential Anti-Inflammatory Agent with Minimal Blood Pressure Effects

This research suggests that pentoxifylline, a xanthine derivative, may possess anti-inflammatory properties without significantly impacting blood pressure. The study found that pentoxifylline treatment led to a significant reduction in plasma levels of TNF-α and CRP, indicating its potential role in modulating inflammation.

Exploring the Potential of Pentoxifylline in Inflammatory Conditions

This study encourages further investigation into the potential therapeutic benefits of pentoxifylline in managing inflammatory conditions. The research findings suggest that pentoxifylline may offer a unique approach to reducing inflammation without significantly altering blood pressure, potentially contributing to the development of novel therapeutic strategies.

Dr. Camel's Conclusion

This research, much like a camel navigating a vast desert of scientific knowledge, explores the potential of pentoxifylline in modulating inflammation. The study's findings suggest that pentoxifylline may offer a promising avenue for managing inflammatory conditions without significantly affecting blood pressure. This research encourages further exploration of pentoxifylline's potential as a therapeutic agent, potentially leading to new insights and advancements in the treatment of inflammatory diseases.

Date :
  1. Date Completed 2017-08-18
  2. Date Revised 2022-03-18
Further Info :

Pubmed ID

27512972

DOI: Digital Object Identifier

10.1097/HJH.0000000000001086

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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