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The chemical class of quinazoline compounds provides a core structure for the design of anticytomegaloviral kinase inhibitors.

Author: BahsiH, ChouS, HamiltonS, HauptV J, HuttererC, MarschallM, NaingZ, RawlinsonW, SocherE, SteingruberM, StichtH, ThumaN, ZeitträgerI, ÖrfiL, ÖrfiZ

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Novel quinazolines Vi7392 and Vi7453 show high antiviral activity against HCMV laboratory and clinically relevant strains, including maribavir- and ganciclovir-resistant variants.
Paper Details　
Original Abstract of the Article :
HCMV is a member of the family Herpesviridae and represents a worldwide distributed pathogen with seropositivity rates in the adult population ranging between 40% and 90%. Notably, HCMV infection is a serious, sometimes life-threatening medical problem for newborns and immunosuppressed individuals, ...See full text at original site
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引用元：
https://doi.org/10.1016/j.antiviral.2016.08.005

データ提供：米国国立医学図書館（NLM）

A New Weapon in the Fight Against Cytomegalovirus

The [cytomegalovirus (CMV)] is a widespread and potentially serious pathogen, particularly for [immunocompromised individuals]. This study investigates the [anticytomegaloviral activity] of [quinazoline compounds], a class of kinase inhibitors. The authors demonstrate that [novel quinazolines Vi7392 and Vi7453] exhibit [potent antiviral activity] against a range of [HCMV strains], including [maribavir- and ganciclovir-resistant variants]. These findings suggest that [quinazolines] may represent a [promising new therapeutic option] for treating CMV infection, offering a potential solution to the challenges posed by [drug resistance and toxicity] associated with current therapies.

A New Path Through the Desert of Cytomegalovirus Infection

The desert of cytomegalovirus infection can be a dangerous and unforgiving landscape for immunocompromised individuals. This research offers a potential path forward by highlighting the antiviral activity of quinazoline compounds. These findings suggest that these compounds may represent a valuable weapon in the fight against CMV, providing a beacon of hope for patients facing this challenging infection.

A Beacon of Hope in the Desert of CMV Infection

This research offers a beacon of hope in the desert of CMV infection. By highlighting the potent antiviral activity of quinazoline compounds, this study suggests a potential new path forward in the fight against this widespread and potentially serious pathogen. These findings encourage continued research and development of these compounds as a promising new therapeutic option for treating CMV infection, offering a glimmer of hope for patients facing this challenging disease.

Dr. Camel's Conclusion

This study underscores the potential of quinazoline compounds as a promising new therapeutic option for treating cytomegalovirus infection. Their potent antiviral activity against a range of HCMV strains, including drug-resistant variants, offers a glimmer of hope in the desert of CMV infection, providing a potential path forward in the fight against this widespread and potentially serious pathogen. These findings encourage continued research and development of these compounds as a valuable tool for treating CMV infection.

Date :
  1. Date Completed 2017-11-16
  2. Date Revised 2018-02-12
Further Info :

Pubmed ID

27515131

DOI: Digital Object Identifier

10.1016/j.antiviral.2016.08.005

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English

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