Effects of agmatine on chlorpromazine toxicity in the liver of Wistar rats: the possible role of oxidant/antioxidant imbalance.

Author: AnaDjuric, BratislavDejanovic, IrenaLavrnja, IvanaStevanovic, IvanaStojanovic, MilicaNinkovic, SandaDilber

Paper Details 
Original Abstract of the Article :
Chlorpromazine (CPZ) is a member of a widely used class of antipsychotic agents. The metabolic pathways of CPZ toxicity were examined by monitoring oxidative/nitrosative stress markers. The aim of the study was to investigate the hypothesis that agmatine (AGM) prevents oxidative stress in the liver ...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300998/

データ提供:米国国立医学図書館(NLM)

Agmatine's Protective Role Against Chlorpromazine Toxicity in the Liver

The human liver is a vital organ, akin to a fertile oasis in the desert, responsible for detoxifying harmful substances. This study focuses on the potential protective effects of agmatine, a naturally occurring compound, against the liver toxicity induced by chlorpromazine, an antipsychotic medication. The researchers explore the role of agmatine in mitigating oxidative stress in the liver, a key factor contributing to chlorpromazine-induced toxicity.

Agmatine's Protective Effects Against Oxidative Stress

The study found that agmatine effectively increased the antioxidant capacity of the liver, reducing the oxidative stress caused by chlorpromazine. This suggests that agmatine could potentially play a role in protecting the liver from the harmful effects of certain medications. Just as a camel's body adapts to the harsh desert environment, agmatine appears to help the liver combat the damaging effects of chlorpromazine.

Protecting the Liver from Medication Toxicity

This research highlights the importance of understanding the potential side effects of medications and developing strategies to mitigate them. The authors suggest that agmatine could offer a valuable tool for protecting the liver from medication-induced toxicity. Just as a skilled desert traveler uses knowledge of the terrain to avoid danger, this research provides valuable insights into protecting the liver from potential harm.

Dr.Camel's Conclusion

This study provides compelling evidence that agmatine possesses protective effects against chlorpromazine-induced liver toxicity. It underscores the importance of exploring natural compounds for their potential therapeutic benefits, particularly in mitigating drug-induced side effects. This research is a testament to the ongoing quest to discover new solutions for protecting human health.
Date :
  1. Date Completed 2017-03-01
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

27523096

DOI: Digital Object Identifier

PMC5300998

Related Literature

SNS
PICO Info
in preparation
Languages

English

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